Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Subscriptions

Quantitative in vivo X-ray dark-field radiography for early pulmonary emphysema diagnosis

Katharina Hellbach, Andre Yaroshenko, Felix G. Meinel, Martin Bech, Oliver Eickelberg, Fabian Bamberg, Konstantin Nikolaou, Maximilian F. Reiser, Ali Ö. Yildirim, Franz Pfeiffer
European Respiratory Journal 2014 44: P4967; DOI:
Katharina Hellbach
1Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andre Yaroshenko
2Department of Physics and Institute of Medical Engineering, Technische Universität München, Garching, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Felix G. Meinel
1Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin Bech
2Department of Physics and Institute of Medical Engineering, Technische Universität München, Garching, Germany
3Medical Radiation Physics, Lund University, Lund, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Oliver Eickelberg
4Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munich, Neuherberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fabian Bamberg
1Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Konstantin Nikolaou
1Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maximilian F. Reiser
1Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ali Ö. Yildirim
4Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Munich, Neuherberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Franz Pfeiffer
2Department of Physics and Institute of Medical Engineering, Technische Universität München, Garching, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Aims: Using conventional chest X-ray imaging it is hardly possible to visualize early stages of emphysema. The aim of this study was to evaluate whether mild to moderate emphysema can be diagnosed in vivo using X-ray dark-field radiography.

Materials/Methods: Female C57Bl/6N mice were used for the experiments. Emphysema was induced by orotracheal injection of elastase. Control mice received orotracheal injection of PBS. To ensure the development of different stages of emphysema anesthetized and freely breathing mice were scanned 7, 14 and 21 days after application of elastase or PBS. Images were acquired with a prototype grating-based small animal scanner and processed using Fourier decomposition to generate transmission as well as dark-field radiographs. In vivo pulmonary function tests were performed before sacrificing the animals. Lungs were obtained for further histopathological analysis (e.g. mean cord length (MCL-) quantification). Three blinded readers, all of them experienced radiologists who are familiar with dark-field imaging, were asked to stage the severity of emphysema for dark-field and transmission images.

Results: As confirmed by MCL-quantifications lungs in the elastase group had developed different stages of emphysema. Correlation of MCL and dark-field signal intensity (r=0,86) was significantly better than correlation of MCL and transmission signal intensity (r=0,37). Visual ratings for dark-field intensity correlated better with MCL (r=0,82) than those for transmission images (r=0,55).

Conclusion: Using X-ray dark-field radiography it is possible to visualize and diagnose mild to moderate emphysema in vivo with a conventional imaging method for the first time.

  • COPD - diagnosis
  • Animal models
  • Experimental approaches
  • © 2014 ERS
Previous
Back to top
Vol 44 Issue Suppl 58 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Quantitative in vivo X-ray dark-field radiography for early pulmonary emphysema diagnosis
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Quantitative in vivo X-ray dark-field radiography for early pulmonary emphysema diagnosis
Katharina Hellbach, Andre Yaroshenko, Felix G. Meinel, Martin Bech, Oliver Eickelberg, Fabian Bamberg, Konstantin Nikolaou, Maximilian F. Reiser, Ali Ö. Yildirim, Franz Pfeiffer
European Respiratory Journal Sep 2014, 44 (Suppl 58) P4967;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Quantitative in vivo X-ray dark-field radiography for early pulmonary emphysema diagnosis
Katharina Hellbach, Andre Yaroshenko, Felix G. Meinel, Martin Bech, Oliver Eickelberg, Fabian Bamberg, Konstantin Nikolaou, Maximilian F. Reiser, Ali Ö. Yildirim, Franz Pfeiffer
European Respiratory Journal Sep 2014, 44 (Suppl 58) P4967;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Do doctors understand the test characteristics of lung cancer screening? – A randomized trial
  • Applicative value of chest HRCT for bronchiectasis evaluating in pulmonary infection with pseudomonas aeruginosa in patients with cystic fibrosis
  • LATE-BREAKING ABSTRACT: Molecular imaging with CXCR4-gallium-68-pentixafor PET correlates with GAP index and treatment effects in idiopathic pulmonary fibrosis
Show more 1.3 Imaging

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society