Abstract
Introduction
Nosocomial lower respiratory tract infections (LRTI) caused by multi-drug resistant pathogens (MDR) are major threat to the hospitalized patients.Extended-Spectrum-beta-Lactamase (ESBL) producing pathogens are becoming a major concern to treat by medical practitioners now-a-days placing an extra burden on individual patients and on healthcare system.
Aims and objectives
The objectives of this study were to determine the aetiology of nosocomial LRTI along with multidrug resistant bacterial strains producing ESBL.
Methods
A total of 100 bacterial isolates from the patients diagnosed of nosocomial LRTI were studied over a period of one year from March 2011 to February 2012 at Department of Microbiology, Tribhuvan University Teaching Hospital (TUTH). A Combination disk method was done for the detection of ESBL-producing isolates according to guidelines of Clinical Laboratory Standard Institute (CLSI).
Results
Out of total bacterial isolates Acinetobacter calcoaceticus baumannii(Acb) complex was found to more predominant(37%) which were followed by Klebsiella pnemoniae(27%).Alarmingly, (31%) bacterial isolates were recovered ESBL producers in which P. aeruginosa was found to be more predominant(41.2%) followed by K. pnemoniae(29.6%).
Conclusions
We found a high prevalence of MDR bacterial strains producing ESBL in our hospital which prompts a special attention for the management of such patients as well as urgent need for implementation of infection control strategies to prevent the dissemination of such strains.
- © 2014 ERS
