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Validation of the global lung function initiative (GLI) spirometry reference equations in school age Spanish children

Ignacio Iglesias, Maite Benavides, Yanny Paola Delgado, Inés Mir, Sandra Rovira, Alba Torrent, Silvia Gartner, Antonio Moreno-Galdó
European Respiratory Journal 2014 44: P4519; DOI:
Ignacio Iglesias
1Pediatric Pulmonology Unit, Hospital Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
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Maite Benavides
1Pediatric Pulmonology Unit, Hospital Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
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Yanny Paola Delgado
1Pediatric Pulmonology Unit, Hospital Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
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Inés Mir
1Pediatric Pulmonology Unit, Hospital Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
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Sandra Rovira
1Pediatric Pulmonology Unit, Hospital Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
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Alba Torrent
1Pediatric Pulmonology Unit, Hospital Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
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Silvia Gartner
1Pediatric Pulmonology Unit, Hospital Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
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Antonio Moreno-Galdó
1Pediatric Pulmonology Unit, Hospital Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
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Abstract

Introduction. Recently published multi-ethnic spirometry reference equations for Caucasian subjects from 3 to 95 years (Quanjer et al Eur Respir J 2012) provide a worldwide standard for interpreting spirometric test results.

Objective. To assess how well the GLI equations fit spirometry data from "healthy" Spanish school age children, in order to verify the appropriateness of this reference for clinical use in this population.

Methods. Two spirometric measurements (n=722/603) were obtained, according to ERS/ATS guidelines, at 7 randomly selected schools from Barcelona (Spain) in children aged 7 to 14.9 years, with a mean (SD) interval between the two tests of 54.3 days (35.3) (range 10 – 135 days). Z-scores were calculated for the spirometry outcomes based on the GLI equations. If there was no offset between the reference and test populations, the mean (SD) z-scores of the test population would be 0 (1). A difference of ≥ 0.5 z-score was considered to be clinically significant.

Results. Of 722 children recruited, 662 were White and 442 (66.8%) fulfilled our criteria as 'healthy'. Of these 71.9% performed technically acceptable and reproducible manoeuvres.

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Conclusions. The finding of values outside 0.5 z-scores of GLI predicted values suggests poor fit with GLI equations. Reasons for these discrepancies should be investigated before applying the GLI equations in Spanish school age children.

  • Spirometry
  • Children
  • Lung function testing
  • © 2014 ERS
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Validation of the global lung function initiative (GLI) spirometry reference equations in school age Spanish children
Ignacio Iglesias, Maite Benavides, Yanny Paola Delgado, Inés Mir, Sandra Rovira, Alba Torrent, Silvia Gartner, Antonio Moreno-Galdó
European Respiratory Journal Sep 2014, 44 (Suppl 58) P4519;

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Validation of the global lung function initiative (GLI) spirometry reference equations in school age Spanish children
Ignacio Iglesias, Maite Benavides, Yanny Paola Delgado, Inés Mir, Sandra Rovira, Alba Torrent, Silvia Gartner, Antonio Moreno-Galdó
European Respiratory Journal Sep 2014, 44 (Suppl 58) P4519;
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