Abstract
Rationale: COPD is an independent risk factor for coronary artery disease (CAD) and cardiovascular (CV) disease is one of the main causes of death in COPD patients.
Objectives: Compare the different non-invasive CV risk tools in COPD patients.
Methods: COPD patients of all degree of severity were prospectively recruited from January 2001 to August 2012. At enrollment we measured: lipid profile, CRP, urine albumine/creatinine ratio, Framingham, SCORE, BODE and its components, coronary artery calcium (CAC) and epicardial adipose tissue (EAT). Their predictive power of CV events was then compared.
Results: Patients characteristics are shown in Table 1
.The median follow-up was 34 months (IQR: 7.8 to 72 months) with a total of 84 recorded CV events: 20 (24%) AMI, 19 (21%) ischemic heart disease/angina, 28 (34%) peripheral artery disease and 18 (21%) strokes.Twelve deaths ocurred, 3 (25%) from CV disease. Table 2 shows the univariate analysis exploring the independent association of each of the risk assessment tools with the ocurrence of CV event. Table 3 shows the multivariate analysis identifying those with the best predictive power. The under area curve (UAC) were: CAC (c statistic = 0.65), Framingham (c stat=0.602), SCORE (c stat=0.55), EAT (c stat=0.52) and 6MWD (c stat=0.65).
Conclusions: In this population of well-characterised COPD patients, CAC and the 6MWD were the best independent predictors of CV events.
- © 2014 ERS