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Importance of flexible broncoscopy in immunocompromised children with pulmonary infections

Nesibe Gevher Eroglu Ertugrul, Ebru Yalçin, Nagehan Emiralioglu, Berna Oguz, Aydin Erden, Baris Kuskonmaz, Deniz Dogru, Ugur Özçelik, Ilhan Tezcan, Nural Kiper
European Respiratory Journal 2014 44: P3461; DOI:
Nesibe Gevher Eroglu Ertugrul
1Department of Pediatrics, Hacettepe University, Ankara, Turkey
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Ebru Yalçin
2Department of Pediatric Pulmonology, Hacettepe University, Ankara, Turkey
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Nagehan Emiralioglu
2Department of Pediatric Pulmonology, Hacettepe University, Ankara, Turkey
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Berna Oguz
3Department of Radiology, Hacettepe University, Ankara, Turkey
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Aydin Erden
4Department of Anesthesiology and Reanimation, Hacettepe University, Ankara, Turkey
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Baris Kuskonmaz
5Department of Peadiatric Hematology, Hacettepe University, Ankara, Turkey
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Deniz Dogru
2Department of Pediatric Pulmonology, Hacettepe University, Ankara, Turkey
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Ugur Özçelik
2Department of Pediatric Pulmonology, Hacettepe University, Ankara, Turkey
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Ilhan Tezcan
6Department of Peadiatric Immunology, Hacettepe University, Ankara, Turkey
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Nural Kiper
2Department of Pediatric Pulmonology, Hacettepe University, Ankara, Turkey
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Abstract

INTRODUCTION

Pulmonary infections are frequently seen in immunocomprimised children.

AIMS

1. To determine the importance of FB and BAL analysis in showing the agent of pulmonary infected immunocompromised children.

2. To investigate the differences of agents and radiological findings between the pulmonary infections arised after BMT and other immunocompromised cases.

3. To evaluate the reliability of radiological findings in showing the agent.

METARIALS AND METHODS

FB and BAL analysis for 79 immunocompromised and pulmonary infected children are retrospectively studied and divided into two groups. Children in group I (n=61) are the primary or secondary immunosupressed patients applied FB and BAL because of pulmonary infections. Children in group II (n=18) are the patients applied FB and BAL because of pulmonary infections after BMT.

RESULTS

In BAL sample analysis, the microorganism was shown in 37 (60,6%) patients of group I and 7 (38,8%) patients of group II. When the microbiological agents compared, the bacterial growth in BAL samples was higher in group I (p=0,017). For the other agents there was no significant difference. No relation between HRCT findings and the agents shown in BAL could be found.

After the analysis of all diagnostic tools related with FB, it was determined that 62/79 (78%) of all patients could be diagnosed. In 32/79 (%40) of all patients the agent was exactly shown and therapy changed.

CONCLUSION

Although FB is applied under empirical anti-microbiological therapy, the importance of BAL analysis in showing the agent of pulmonary infection in immunocompromised children and it's contribution to diagnosis is found to be high.

  • Bronchoalveolar lavage
  • Immunosuppression
  • Infections
  • © 2014 ERS
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Importance of flexible broncoscopy in immunocompromised children with pulmonary infections
Nesibe Gevher Eroglu Ertugrul, Ebru Yalçin, Nagehan Emiralioglu, Berna Oguz, Aydin Erden, Baris Kuskonmaz, Deniz Dogru, Ugur Özçelik, Ilhan Tezcan, Nural Kiper
European Respiratory Journal Sep 2014, 44 (Suppl 58) P3461;

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Importance of flexible broncoscopy in immunocompromised children with pulmonary infections
Nesibe Gevher Eroglu Ertugrul, Ebru Yalçin, Nagehan Emiralioglu, Berna Oguz, Aydin Erden, Baris Kuskonmaz, Deniz Dogru, Ugur Özçelik, Ilhan Tezcan, Nural Kiper
European Respiratory Journal Sep 2014, 44 (Suppl 58) P3461;
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