Abstract
Rationale
Current ACCP guidelines (Chest 2007) recommend usage of segment count and perfusion scintigraphy method for calculating post-operative FEV1 (poFEV1) in patients undergoing lob/pneumonectomy, respectively. In this trial, functional respiratory imaging (FRI) is evaluated for calculating poFEV1.
Methods
23 pts (14 analyzed/9 dropouts) were included. All patients underwent spirometry, perfusion scanning, and HRCT scans at RV and TLC. Post-surgery tests were acquired after recovery and before starting adjuvant therapy. FRI analysis provided regional expansion (EXP) and resistance (iRaw, before and after virtual resection). poFEV1 was predicted using ACCP formulas and (for FRI):
Results
Conclusions
In contrast with ACCP, FRI predicted and measured poFEV1 are not significantly different. RMSE of FRI method is 43% smaller than ACCP, and is lower than the minimally important changes in FEV1 (323 ml, Respiratory Medicine 2013). Also, the slope of the linear fit from the FRI prediction is very close to 1, indicating that the model is very well predicting reality. FRI seems to be a better tool to predict poFEV1 as compared to ACCP.
This study was funded by IWT.
- © 2014 ERS
