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Dynamic changes of Th1-cell immune response to ESAT-6 and CFP-10 during anti-tuberculosis treatment

Lifan Zhang, Qiang Li, Yueqiu Zhang, Yanhua Song, Mengqiu Gao, Xiaochun Shi, Yanbin Zhang, Yao Zhang, Ajit Lalvani, Xiaoqing Liu
European Respiratory Journal 2014 44: P3063; DOI:
Lifan Zhang
1Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Qiang Li
1Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Yueqiu Zhang
1Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Yanhua Song
1Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Mengqiu Gao
1Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Xiaochun Shi
1Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Yanbin Zhang
1Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Yao Zhang
1Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Ajit Lalvani
1Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Xiaoqing Liu
1Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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  • Frequencies of cytokine secreting T cells in TB patients during treatment

    AntigensCytokinesFrequencies(Median[IQR],iSFCs/10e6 PBMC)P value
      Baseline6 months after treatment 
    ESAT-6IFN-γ-only272[66-815]62[21-156]0.006
     IL-2-only38[11-142]30[7-68]0.119
     Dual IFNγ/IL-28[0-45]20[0-65]0.575
    CFP-10IFN-γ-only166[60-286]62[9-225]0.006
     IL-2-only4[0-132]14[4-46]0.694
     Dual IFNγ/IL-24[0-14]12[0-30]0.046
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Dynamic changes of Th1-cell immune response to ESAT-6 and CFP-10 during anti-tuberculosis treatment
Lifan Zhang, Qiang Li, Yueqiu Zhang, Yanhua Song, Mengqiu Gao, Xiaochun Shi, Yanbin Zhang, Yao Zhang, Ajit Lalvani, Xiaoqing Liu
European Respiratory Journal Sep 2014, 44 (Suppl 58) P3063;

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Dynamic changes of Th1-cell immune response to ESAT-6 and CFP-10 during anti-tuberculosis treatment
Lifan Zhang, Qiang Li, Yueqiu Zhang, Yanhua Song, Mengqiu Gao, Xiaochun Shi, Yanbin Zhang, Yao Zhang, Ajit Lalvani, Xiaoqing Liu
European Respiratory Journal Sep 2014, 44 (Suppl 58) P3063;
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