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The influence of heredity on the persistence and onset-age of asthma

Elina M.S. Paaso, Maritta S. Jaakkola, Aino K. Rantala, Timo T. Hugg, Jouni J.K. Jaakkola
European Respiratory Journal 2014 44: P2990; DOI:
Elina M.S. Paaso
1Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland
2Respiratory Medicine Unit, Department of Medicine, Oulu University Hospital, Oulu, Finland
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Maritta S. Jaakkola
1Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland
2Respiratory Medicine Unit, Department of Medicine, Oulu University Hospital, Oulu, Finland
3Respiratory Medicine Unit, Institute of Clinical Medicine, University of Oulu, Oulu, Finland
4Medical Research Center Oulu, University of Oulu, Oulu, Finland
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Aino K. Rantala
1Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland
5Public Health, Institute of Health Sciences, University of Oulu, Oulu, Finland
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Timo T. Hugg
1Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland
4Medical Research Center Oulu, University of Oulu, Oulu, Finland
5Public Health, Institute of Health Sciences, University of Oulu, Oulu, Finland
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Jouni J.K. Jaakkola
1Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland
2Respiratory Medicine Unit, Department of Medicine, Oulu University Hospital, Oulu, Finland
4Medical Research Center Oulu, University of Oulu, Oulu, Finland
5Public Health, Institute of Health Sciences, University of Oulu, Oulu, Finland
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Abstract

Background: Parental asthma has been linked to personal asthma previously, but the effects of heredity on the persistence and onset-age of asthma until young adulthood need further studies.

Objectives: We investigated the influence of heredity on transient vs. persistent and early-onset vs. late-onset asthma in the Espoo Cohort Study 20-year follow-up of 1623 people (63.2% of the baseline).

Methods: Asthmatics (n = 220) were divided into persistent asthma according to symptoms and/or medication in the follow-ups after the initial diagnosis of asthma and transient if otherwise. Persistent asthma was divided into early- and late-onset asthma using the age of 13 years as cut-point. The determinants were any heredity (any parent or sibling); maternal; paternal; both parents; siblings only; parents only and both siblings and parents. Adjusted risk ratios (RRa) were calculated with Poisson regression and Q-statistics to calculate heterogeneity between RRs.

Results: Heredity influenced all the subtypes but in various ways. Most hereditary determinants had a stronger impact on persistent asthma than transient, but siblings only had a similar impact on both (persistent: RRa = 2.16, 95% CI = 1.27-3.68; transient: RRa = 2.10, 95% CI = 1.15-3.86; heterogeneity P = 0.95). Maternal asthma seemed to effect only early-onset asthma (RRa = 2.75, 95% CI = 1.62-4.69) while the impact of paternal asthma continued (early: RRa = 2.28, 95% CI = 1.15-4.53; late: RRa = 1.98, 95% CI = 0.76-5.15; heterogeneity P = 0.81).

Conclusions: Heredity plays the most important role in persistent and early-onset asthma. The impact of paternal asthma continues to young adulthood while the influence of maternal asthma decreases with age.

  • Asthma - diagnosis
  • Epidemiology
  • Longitudinal study
  • © 2014 ERS
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The influence of heredity on the persistence and onset-age of asthma
Elina M.S. Paaso, Maritta S. Jaakkola, Aino K. Rantala, Timo T. Hugg, Jouni J.K. Jaakkola
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2990;

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The influence of heredity on the persistence and onset-age of asthma
Elina M.S. Paaso, Maritta S. Jaakkola, Aino K. Rantala, Timo T. Hugg, Jouni J.K. Jaakkola
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2990;
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