Abstract
Aim:To study the gene expression of Epidermal growth factor receptor(EGFR),MYC-induced nuclear antigen 53kDa(MINA53),Multiple endocrine neoplasia type 1(MEN1) and Mechanistic target of rapamycin(MTOR) in non-small cell lung carcinomas(NSCLC),and their correlations and prognostic significance.
Methods:Surgically resected specimens from 57 NSCLC patients were studied:29 adenocarcinomas(AC) and 28 squamous cell carcinomas(SCC).Histological subtype,pTNM stage,survival and gene expression of EGFR,MINA53,MEN1 and MTOR were evaluated.
Results:Overexpression of EGFR was found in 46%(17 SCC&9 AC),MINA53–54%(14SCC&17 AC),MEN1–53%(16SCC&14AC) and MTOR–25%(5SCC&9AC).Decreased expression of EGFR was found in 11%(2SCC&4 AC),MINA53–1 SCC,MEN1-2 AC and MTOR–5%(1 SCC&2 AC).Co-overexression of the 4 genes was found in 11%(4 SCC&2 AC).AC were more often with normal/decreased expression of EGFR(69%), while SCC-more often with overexpression(61%)(p=0.03),confirmed by regression analysis(Odds ratio 3.43;p=0.03).
No prognostic significance of EGFR, MINA53,MEN1 or MTOR expression was found with Kaplain-Meier and Cox regression analysis (p>0.05).
In SCC statistically significant correlations between EGFR&MEN1(p<0.001),EGFR&MTOR(p=0.01),MINA53&MTOR(p=0.004) and MEN1&MTOR(p=0.02) were observed.In AC statistically significant correlations between MINA53&MTOR(p=0.02) and MEN1&MTOR(p=0.01) were observed. MEN1 overexpression correlates with early stage(p=0.02).
Conclusion:EGFR,MINA53,MEN1 and MTOR are often overexpressed in NSCLCs and there are positive correlations between their expression levels making them potential targets for combined therapy. They don't show a prognostic significance, although MEN1 overexpression correlate with early stage.
- © 2014 ERS