Abstract
Background:Poverty and overcrowding in urban slums creates hot spots for initial drug resistant tuberculosis. One such area is the M (east) ward in Mumbai, India.
Aim:
1. To identify factors for drug resistant TB in urban slums
2. Study resistance patterns to anti-TB drugs
Method: Retrospective analysis of records at a tertiary care hospital in Navi Mumbai was done. Patients from M (east) ward in Mumbai were included. Multidrug resistant (MDR) and extensively drug resistant (XDR) TB were diagnosed by analysis of sputum/relevant samples by Line probe assay, liquid culture and sensitivity.
Results:
38 patients (23 men,15 women), had drug resistant TB. 33(84%) had MDR, 5(16%) XDR TB. No HIV/diabetes.
Initial drug resistance - MDR-5/33 (15%). XDR-1/5(20%).
Contact history- 6/38 (15%) cases.
Causes identified in each group-
Causes of drug resistance
Drug resistance:
High degree of initial drug resistance to quinolones found in MDR(67%) patients.
Conclusion: 1.50% of patients in urban slum area with drug resistant TB had no identified cause.
2. High prevalence of drug resistance in the community contributes to this .
3. 67% MDR isolates resistant to quinolones.
4. Drug susceptibility at the outset will be useful in such areas.
- © 2014 ERS
