Abstract
Objectives: to determine the significance of different clinical, inflammatory (procalcitonin (PCT) and C-reactive protein (CRP)), immunological (CD4, CD8) markers as predictors of survival in patients with severe CAP.
Methods: 51 patients with verified severe CAP without HIV (age – 57,50±4,31 years, men – 37 (72,5%),women – 14 (27,5%)). General analysis, SMRT-CO count, determination of serum PCT and CRP, blood CD4, CD8 prior antibacterial therapy (ABT) (visit 1), on 8–10 day of ABT (visit 2) with count of delta (v 2-1), statistic including factor loading.
Results: in 6 (11,7%) patients with severe CAP, despite adequate ABT, lethal end of disease was determined. Statistical value on survival of different parameters is present in table (maximum is 1)
Factor loading of different parameters in patients with severe CAP
.
Conclusions: 1) initial SMRT-CO count cannot serve as a predictor of survival in patients with severe CAP; 2) feature of survival predicting in patients with severe CAP is the complex account of immune and inflammatory markers; 3) the most significant laboratory predictors of outcome in patients with severe CAP is individual dynamic of CD4 and PCT.
- © 2014 ERS
