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Clinical impact of the complications related to lung transplantation

Ana Verónica Cardoso, Helder Novais e Bastos, Carla Damas
European Respiratory Journal 2014 44: P2459; DOI:
Ana Verónica Cardoso
1Department of Pneumology, São João Hospital Centre, Porto, Portugal
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Helder Novais e Bastos
1Department of Pneumology, São João Hospital Centre, Porto, Portugal
2Health Sciences School, University of Minho, Braga, Portugal
3Life and Health Sciences Research Institute, University of Minho, Braga, Portugal
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Carla Damas
1Department of Pneumology, São João Hospital Centre, Porto, Portugal
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Abstract

Introduction: For selected patients, lung transplantation (LT) prolongs survival and improves quality of life. However, it is also associated with complications with high morbidity.

Objective: To evaluate the impact of the complications associated to LT in quality of life and functional status of transplanted patients.

Methods: Analysis of the complications and its correlation with quality of life, physical limitation and anxiety/depression, evaluated, respectively, by applying the Medical Outcomes Study Short Form-36 (SF-36), the scale London Chest Activity of Daily Living (LCADL) and the Hospital Anxiety and Depression Scale (HADS).

Results: 30 transplanted patients were included. The most frequent complications were: osteoporosis (46.7%), CMV infection (40%), renal dysfunction (33.3%) and dyslipidemia (33.3%). There was a negative correlation between complications number and quality of life in the areas of bodily pain (r=-0.36, p=0.04), vitality (r=-0.37, p=0.04), emotional role functioning (r =-0.37, p=0.04) and mental health (r=-0.39, p=0.03). No significant association was established with the remaining four domains of the SF-36. We found a positive correlation between complications and physical limitations in the field of self-care of LCADL (r=0.45, p=0.01). This association was not observed with other areas neither with the total score of LCADL. Anxiety and depression were not correlated with complications.

Conclusion: The complications associated to LT contribute to decreased quality of life and increased physical limitation of patients. However, the presence of low to moderate associations with only some fields of the SF-36 and LCADL, suggests that there are other factors influencing these variables.

  • Transplantation
  • Quality of life
  • Sepsis
  • © 2014 ERS
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Clinical impact of the complications related to lung transplantation
Ana Verónica Cardoso, Helder Novais e Bastos, Carla Damas
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2459;

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Clinical impact of the complications related to lung transplantation
Ana Verónica Cardoso, Helder Novais e Bastos, Carla Damas
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2459;
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More in this TOC Section

  • Utility of C4d by immunohistochemistry for the diagnosis of antibody-mediated rejection in lung transplantation
  • Inflammation and primary graft dysfunction after lung transplantation: CT-PET findings
  • Exhaled nitric oxide: A biomarker for chronic lung allograft dysfunction?
Show more 8.2 Transplantation

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