Clinical phenotypes in pulmonary emboli identified by cluster analysis

Abstract

Objective: We; in this study, examined the clinical phenotypes in the patients diagnosed with PE and clinical differences of these groups by using cluster analysis.

Method:43 people with the diagnosis of PE were included into this study. PE severity index (PESI) were calculated. In the patients, 9 EKG alteration for PE were evaluated as exists or not and total EKG score were taken. Patients dyspnoea were evaluated by MMRC scale. Life quality was examined for all patients by SF-36. Anxiety depression examinations were made by HAD scale. Patients were divided into 2 groups by cluster analysis .

Results:Group 1; 24 persons were included . Group 1; consisted of younger persons having lower PESI with lower hypoxemia. Group 2; included more advanced age- persons having higher PESI and having more serious hypoxemia

. When Group 1 and 2 are compared in terms of clinical parameters; In Group 1 total EKG score was found lower . SF-36 s mental and physical health components were found higher in Group1 than Group 2. HAD depression component, besides, was found lower in Group1 than Group2 . MMRC was lower in Group 1 than Group 2 at the border. BMI, PaCO2, d-dimer level, HAD anxiety component were not found different between Group 1 and 2.

Conclusion: We can divide the patients with the diagnosis of PE into different phenotypes clinically according to age, hypoxemia and PESI. Cardiac functions of younger patients with light hypoxic and PESI are lower. Yet, life quality of these patients are better and their depressive symptoms are rare.