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The incidence of chronic thromboembolic pulmonary hypertension secondary to acute pulmonary thromboembolism

Ismail Kayaalp, Yelda Varol, Pinar Cimen, Fatma Demirci Ucsular, Nuran Katgi, Mehmet Unlu, Cenk Kirakli, Salih Zeki Guclu, Oktay Ergene
European Respiratory Journal 2014 44: P2318; DOI:
Ismail Kayaalp
1Pulmonology, Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Izmir, Turkey
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Yelda Varol
1Pulmonology, Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Izmir, Turkey
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Pinar Cimen
1Pulmonology, Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Izmir, Turkey
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Fatma Demirci Ucsular
1Pulmonology, Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Izmir, Turkey
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Nuran Katgi
1Pulmonology, Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Izmir, Turkey
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Mehmet Unlu
1Pulmonology, Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Izmir, Turkey
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Cenk Kirakli
1Pulmonology, Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Izmir, Turkey
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Salih Zeki Guclu
1Pulmonology, Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Izmir, Turkey
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Oktay Ergene
2Cardiology, Atatürk Education and Research Hospital, Izmir, Turkmenistan
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Abstract

Chronic thromboembolic pulmonary hypertension(CTEPH) is a curable and preventable complication with a substantial incidence leading to severe morbidity and mortality.The aim of the study was to find out the incidence of CTEPH secondary to acute pulmonary thromboembolism(PTE) using non-invasive procedures such as ventilation/perfusion(V/Q) scintigraphy and pulmonary multidetector CT(MDCT)angiography.The study included a total of 99 patients diagnosed with initial PTE between January 2010 and December 2012.The patients who received anticoagulant therapy at least for 3 months underwent transthoracic echocardiography(TTE)(N=85).Thirtyone patients with a SPAP value>30mmHg and/or an evidence of right ventricular dysfunction in TTE underwent pulmonaryangiography and V/Q scintigraphy.The patients with an evidence of residual chronic thromboembolic signs in MDCTpulmonary angiography and/or segmental perfusion defect(s) in V/Q scintigraphy underwent rightheart catheterization(RHC)(N=7).During diagnosis,24 subjects were considered having massive,61 submassive and 14 non-massive PTE. Nineteen patients(19,1%) received thrombolythic therapy.Other 80 patients(80.8%) received standard anticoagulant therapy.In 79.8% of patients,thromboembolism was bilateral and it was unilateral in 21.8%.After a minimum of 1 year,and maximum of 2 years follow up five subjects(5.5%) were diagnosed with CTEPH.The univariate analysis showed no association between the development of CTEPH and factors like;age,etiologic risk factors for PTE,receiving thrombolytic treatment,prevalence and type of PTE.Potentially preventabl complication of PE;CTEPH had a substantial incidence during follow-up.

  • Pulmonary hypertension
  • Imaging
  • Embolism
  • © 2014 ERS
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The incidence of chronic thromboembolic pulmonary hypertension secondary to acute pulmonary thromboembolism
Ismail Kayaalp, Yelda Varol, Pinar Cimen, Fatma Demirci Ucsular, Nuran Katgi, Mehmet Unlu, Cenk Kirakli, Salih Zeki Guclu, Oktay Ergene
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2318;

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The incidence of chronic thromboembolic pulmonary hypertension secondary to acute pulmonary thromboembolism
Ismail Kayaalp, Yelda Varol, Pinar Cimen, Fatma Demirci Ucsular, Nuran Katgi, Mehmet Unlu, Cenk Kirakli, Salih Zeki Guclu, Oktay Ergene
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2318;
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