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Erythrocytosis and hypopnea syndrome sleep apnea. Effect of CPAP

Carolina Jurkojc, Paola Arrieta, Eva Mañas, Carolina Gotera, Rosa Mirambeaux, Deisy Barrios, Patricia Lazo
European Respiratory Journal 2014 44: P2261; DOI:
Carolina Jurkojc
1Pneumology, H.U.Ramon y Cajal, Madrid, Spain
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Paola Arrieta
1Pneumology, H.U.Ramon y Cajal, Madrid, Spain
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Eva Mañas
1Pneumology, H.U.Ramon y Cajal, Madrid, Spain
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Carolina Gotera
1Pneumology, H.U.Ramon y Cajal, Madrid, Spain
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Rosa Mirambeaux
1Pneumology, H.U.Ramon y Cajal, Madrid, Spain
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Deisy Barrios
1Pneumology, H.U.Ramon y Cajal, Madrid, Spain
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Patricia Lazo
1Pneumology, H.U.Ramon y Cajal, Madrid, Spain
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Abstract

Introduction: Polycythemia is a finding in patients with obstructive sleep apnoea hypopnoea syndrome (SAHS). If the hematocrit (HCT) increase was due to intermittent nocturnal hypoxia, it would be interesting to analyze whether CPAP treatment produces a decrease in HCT, translating a correction of hypoxic events.

Material and Methods : 20 patients referred from the hematology unit for respiratory sleep disorders evaluated during 2012-2013 . They did study with cardiorespiratory polygraphy. Those patients diagnosed with SAHS were treated with CPAP. After 6 months of treatment, underwent a blood test . Hemoglobin (HB) levels and HCT were compared before and after CPAP , using the Wilcoxon test for nonparametric variables.

Results : All patients were male. The mean age was 64.5 (SD 13.6). 85% (17 ) patients were diagnosed with SAHS. The mean respiratory disturbance index ( RDI ) resulted 32.7 (SD 25.6 ) . The minimum was 0.7 and the maximum 81 . Half of the patients showed severe SAHS. The nocturnal oximetry profile presented with an average of 41 % T90 % (SD 35 ) and a middle desaturation index 34.4 / h ( SD 25 ) . A predominance of obstructive SAHS was observed. When comparing HB and HCT before and after treatment with CPAP , a reduction of both parameters was observed , with a significant difference

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Conclusion: Patients with SAHS and poliglobulia show an improvement in red cell parameters after treatment with CPAP. Studies with larger series are needed to verify these results.

  • Sleep disorders
  • Apnoea / Hypopnea
  • Chronic disease
  • © 2014 ERS
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Erythrocytosis and hypopnea syndrome sleep apnea. Effect of CPAP
Carolina Jurkojc, Paola Arrieta, Eva Mañas, Carolina Gotera, Rosa Mirambeaux, Deisy Barrios, Patricia Lazo
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2261;

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Erythrocytosis and hypopnea syndrome sleep apnea. Effect of CPAP
Carolina Jurkojc, Paola Arrieta, Eva Mañas, Carolina Gotera, Rosa Mirambeaux, Deisy Barrios, Patricia Lazo
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2261;
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