Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

Exploring the immune status of sepsis patients through Tim-3 expressed on monocytes and IL-12

Jia Li, Yan Xiao, Longxiang Su, Huijuan Wang, Kun Xiao, Gencheng Han, Lixin Xie
European Respiratory Journal 2014 44: P2079; DOI:
Jia Li
1Department of Respiratory, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yan Xiao
1Department of Respiratory, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Longxiang Su
1Department of Respiratory, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Huijuan Wang
1Department of Respiratory, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kun Xiao
1Department of Respiratory, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gencheng Han
1Department of Respiratory, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lixin Xie
1Department of Respiratory, Chinese PLA General Hospital, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Purpose:Sepsis is a severe infection disease that leads to immune dysfunction. The expression of T cell Ig and mucin domain protein-3(Tim-3) on monocytes has been suggested to be an important immune regulator during infection as it was shown to regulate the production of IL-12 both in vitro and in vivo. The expression of Tim-3 on monocytes and its relationship to IL-12 expression in sepsis patients remain unclear.

Methods: Our study included 36 patients with differing severities of sepsis (12 patients with sepsis, 16 patients with severe sepsis, 8 patients with septic shock) and 11 normal controls. The expression of Tim-3 on monocytes was evaluated by flow cytometry. IL-12 mRNA in peripheralbloodcells was assayed using real-time PCR (RT-PCR).

Results:The expression of Tim-3 on monocytes and IL-12 mRNA were significantly elevated in sepsis and severe sepsis patients in comparison with normal controls. However, Tim-3 and IL-12 levels were significantly decreased in patients with septic shock compared to patients with severe sepsis. The relevant risk factors for death and Tim-3 were evaluated using logistic regression analysis; the odds ratio (OR) for Tim-3 was 1.218 (p<0.05). We found that Tim-3 expression on monocytes was positively correlated with IL-12 expression (Spearman correlation coefficient=0.782, p<0.001).

Conclusion: Our findings indicate that Tim-3 is involved in regulating the function of monocytes in sepsis patients and that low expression of Tim-3 is associated with the immune suppression of monocytes during the early stage of septic shock. Tim-3 may potentially act as an indicator for the prognosis of septic shock and guide future developments of immunotherapy approaches.

  • Sepsis
  • Infections
  • Immunosuppression
  • © 2014 ERS
Previous
Back to top
Vol 44 Issue Suppl 58 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Exploring the immune status of sepsis patients through Tim-3 expressed on monocytes and IL-12
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Exploring the immune status of sepsis patients through Tim-3 expressed on monocytes and IL-12
Jia Li, Yan Xiao, Longxiang Su, Huijuan Wang, Kun Xiao, Gencheng Han, Lixin Xie
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2079;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Exploring the immune status of sepsis patients through Tim-3 expressed on monocytes and IL-12
Jia Li, Yan Xiao, Longxiang Su, Huijuan Wang, Kun Xiao, Gencheng Han, Lixin Xie
European Respiratory Journal Sep 2014, 44 (Suppl 58) P2079;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Acquired coagulation disorders during extracorporeal carbon dioxide removal
  • Aggressive treatment of simple pleural effusion in ventilated patients: Pigtail catheters versus thoracostomy
  • Effect of non-patient-level factors on mortality in intensive care units
Show more 2.1 Acute Critical Care

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2021 by the European Respiratory Society