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Remodeling of bronchial and pulmonary muscular arteries in mild/moderate COPD

Raquel Annoni, Tatiana Lancas, Luiz Fernando Silva, Andreina Bruno, Salvatore Battaglia, Marisa Dolhnikoff, Pieter Hiemstra, Peter Sterk, Klaus Rabe, Thais Mauad
European Respiratory Journal 2014 44: P1849; DOI:
Raquel Annoni
1Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil
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Tatiana Lancas
1Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil
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Luiz Fernando Silva
1Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil
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Andreina Bruno
2Institute of BioMedicine and Molecular Imm, Consiglio Nazionale delle Ricerche, Palermo, Italy
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Salvatore Battaglia
3Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy
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Marisa Dolhnikoff
1Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil
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Pieter Hiemstra
4Department of Pulmonology, Leiden University Medical Center, Leiden, Netherlands
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Peter Sterk
5Department of Respiratory Medicine, University of Amsterdam, Amsterdam, Netherlands
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Klaus Rabe
6Center for Pneumology and Thoracic Surgery, Grosshansdorf Hospital, Grosshansdorf, Germany
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Thais Mauad
1Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil
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Abstract

Pulmonary hypertension is well documented in severe COPD but little is known about vascular remodeling in mild/moderate patients.

Aim:To investigate bronchial and pulmonary muscular arteries morphology and the expression of elastic fibers (EF) and collagen I in the lungs of mild/moderate COPD patients.

Methods:Lung tissue of 18 COPD subject (FEV1:67±15%pred), 14 non-obstructed smokers(NOS) (FEV1:95±10%pred) and 11 never-smoking controls(CTRL) (FEV1:108±15%pred) was used to analyze the morphology of bronchial and pulmonary muscular arteries and the expression of EF and collagen I in the tunica intima, media and adventitia, using immune- and histochemistry and image analysis. Values (mean±SD) were expressed as (stained) area⁄vessel outer perimeter (μm2⁄μm) and as staining density (collagen I).

Results:The intimal areas of pulmonary (CTRL=8.87±4.3, COPD=14.7±5, p=0.04) and the adventitia of bronchial arteries (CTRL=27.7±11.4, COPD=50.6±23.7, p=0.007) were larger in COPD patients than in CTRL. Higher EF expression was observed in adventitia of bronchial arteries of NOS group (8.8±13.2) than CTRL (3.1±1.3, p=0.04). The CTRL group had higher collagen I staining density in the adventitia of bronchial (CTRL=81.6±35.8; NOS=32.8±15; COPD=40.9±25.4, p=0.002) and pulmonary (CTRL=96.5±23.2; NOS=54.8±24; COPD=69.6±19.1, p=0.0005) arteries than NOS and COPD. Within COPD group, negative correlations were observed between the intimal area of pulmonary arteries and FEV1 (R=-0.57, p=0.04) and FEV1⁄FVC (R=-0.56, p=0.04).

Conclusions:Remodeling of bronchial and pulmonary muscular arteries occurs in mild⁄moderate COPD, is associated with impaired lung function and it might contribute to the development of pulmonary hypertension.

  • COPD - mechanism
  • Circulation
  • Morphology
  • © 2014 ERS
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Remodeling of bronchial and pulmonary muscular arteries in mild/moderate COPD
Raquel Annoni, Tatiana Lancas, Luiz Fernando Silva, Andreina Bruno, Salvatore Battaglia, Marisa Dolhnikoff, Pieter Hiemstra, Peter Sterk, Klaus Rabe, Thais Mauad
European Respiratory Journal Sep 2014, 44 (Suppl 58) P1849;

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Remodeling of bronchial and pulmonary muscular arteries in mild/moderate COPD
Raquel Annoni, Tatiana Lancas, Luiz Fernando Silva, Andreina Bruno, Salvatore Battaglia, Marisa Dolhnikoff, Pieter Hiemstra, Peter Sterk, Klaus Rabe, Thais Mauad
European Respiratory Journal Sep 2014, 44 (Suppl 58) P1849;
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