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Biopersistence of nanoparticle in inhalation and intratracheal instillation studies for hazard assessment

Takako Oyabu, Yasuo Morimoto, Byeong-Woo Lee, Takami Okada, Hiroto Izumi, Taisuke Tomonaga, Yukiko Yoshiura, Manabu Shimada, Masaru Kubo, Toshihiko Myojo
European Respiratory Journal 2014 44: P1491; DOI:
Takako Oyabu
1Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
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Yasuo Morimoto
1Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
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Byeong-Woo Lee
1Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
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Takami Okada
1Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
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Hiroto Izumi
1Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
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Taisuke Tomonaga
1Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
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Yukiko Yoshiura
1Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
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Manabu Shimada
2Departnemt of Chemical Engineering, Hiroshima University, Higashi-Hiroshima, Japan
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Masaru Kubo
2Departnemt of Chemical Engineering, Hiroshima University, Higashi-Hiroshima, Japan
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Toshihiko Myojo
1Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
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Abstract

For assessing the inhalation toxicity of nanoparticles, we performed an inhalation study and an intratracheal instillation study of the same material, nickel oxide nanoparticle, at almost the same dose to rat lung and compared the results of the two methods.

In inhalation study, male Fisher 344 rats were exposed to NiO nanoparticles at 0, 1.65±0.20 and 0.32±0.07 mg/m3 for 4 weeks. In instillation study, 0, 0.2, 1 mg of NiO nanoparticle suspended in 0.4 ml distilled water were intratracheally instilled into male Fisher 344 rat's lung. In the recovery period after the inhalation and the instillation, each 10 rats of each group were dissected at from 3 days to 12 months and NiO amounts in 5 lungs each were determined by ICP-AES after acid digestion.

The NiO amounts at 3 days after the inhalation were 40±2.4 μg in low concentration exposure and 132±9.9 μg in high concentration exposure, respectively. And those at 3 days after the instillation were 136±6.5 μg in 0.2 mg and 738±50 μg in 1.0 mg, respectively. The amounts of NiO in lung at 3 days after the high inhalation exposure and those after 0.2 mg instillation were almost the same.

Biological half times of NiO until 6 months were 3.7 months in low and 4.5 months in high inhalation exposure and 4.9 months in 0.2 mg and 9.5 months in 1.0 mg, respectively.

Our results suggested that both inhalation study and instillation study show the similar biopersistence at almost the same lung dose. Further researches are continued.

This work is on the research program of “Development of innovative methodology for safety assessment of industrial nanomaterials" supported by Ministry of Economy, Trade and Industry (METI) of Japan.

  • Experimental approaches
  • Lung injury
  • Occupation
  • © 2014 ERS
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Biopersistence of nanoparticle in inhalation and intratracheal instillation studies for hazard assessment
Takako Oyabu, Yasuo Morimoto, Byeong-Woo Lee, Takami Okada, Hiroto Izumi, Taisuke Tomonaga, Yukiko Yoshiura, Manabu Shimada, Masaru Kubo, Toshihiko Myojo
European Respiratory Journal Sep 2014, 44 (Suppl 58) P1491;

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Biopersistence of nanoparticle in inhalation and intratracheal instillation studies for hazard assessment
Takako Oyabu, Yasuo Morimoto, Byeong-Woo Lee, Takami Okada, Hiroto Izumi, Taisuke Tomonaga, Yukiko Yoshiura, Manabu Shimada, Masaru Kubo, Toshihiko Myojo
European Respiratory Journal Sep 2014, 44 (Suppl 58) P1491;
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