Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Subscriptions

Comparison of pulmonary inflammatory responses between intratracheal instillation and inhalation of nanoparticles

Hiroto Izumi, Yasuo Morimoto, Masanori Horie, Yukiko Yoshiura, Taisuke Tomonaga, Byeong-Woo Lee, Takami Okada, Takako Oyabu, Toshihiko Myojo, Manabu Shimada, Masaru Kubo, Kazuhiro Yamamoto, Shinichi Kitajima
European Respiratory Journal 2014 44: P1490; DOI:
Hiroto Izumi
1IIES, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yasuo Morimoto
1IIES, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masanori Horie
1IIES, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yukiko Yoshiura
1IIES, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Taisuke Tomonaga
1IIES, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Byeong-Woo Lee
1IIES, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takami Okada
1IIES, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takako Oyabu
1IIES, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Toshihiko Myojo
1IIES, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Manabu Shimada
2Department of Chemical Engineering, Hiroshima University, Higashi-Hiroshima, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masaru Kubo
2Department of Chemical Engineering, Hiroshima University, Higashi-Hiroshima, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazuhiro Yamamoto
3RIIF, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shinichi Kitajima
4Division of Research and Examination, National Sanatorium Hoshizuka Keiaien, Kagoshima, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

The objectiveof this study is whether or not intratracheal instillation study is useful for screening of harmful effect of nanoparticles before inhalation study. As a first step, we performed inhalation and intratracheal instillation studies using same sample of nanoparticles, and compared with pulmonary inflammation between both studies. Nickel oxide nanoparticles (NiO) and titanium dioxide nanoparticles (TiO2) were used as chemicals with high and low toxicities, respectively. In intratracheal instillation study, rats were exposed to 0.2mg or 1mg of NiO or TiO2. In inhalation study, rats were exposed to inhaled NiO or TiO2 (1.65-1.84 mg/m3) for 4 weeks (6hours/day, 5 days/week). Cell analysis and chemokines in bronchoalveolar lavage fluid (BALF) were analyzed at 3 days and 1month after end of exposure in both studies.

NiO induced total and neutrophil number in BALF and concentration of CINC-1 in both studies. Compared with inhalation studies, the tendency of persistent inflammationis observed in intratracheal instillation study. TiO2 transiently induced neutrophil number in BALF at acute phase (3days) in intratracheal instillation study, however did not induce pulmonary inflammation in inhalation study. Taken together difference in pulmonary response is observed at acute phase in both studies, and it suggested that the pulmonary inflammation is evaluated not only acute phase but also chronic phase.

This work is partially supported by “Development of innovative methodology for safety assessment of industrial nanomaterials" by Ministry of Economy, Trade and Industry (METI) of Japan.

  • Infections
  • Public health
  • Lung injury
  • © 2014 ERS
Previous
Back to top
Vol 44 Issue Suppl 58 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Comparison of pulmonary inflammatory responses between intratracheal instillation and inhalation of nanoparticles
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Comparison of pulmonary inflammatory responses between intratracheal instillation and inhalation of nanoparticles
Hiroto Izumi, Yasuo Morimoto, Masanori Horie, Yukiko Yoshiura, Taisuke Tomonaga, Byeong-Woo Lee, Takami Okada, Takako Oyabu, Toshihiko Myojo, Manabu Shimada, Masaru Kubo, Kazuhiro Yamamoto, Shinichi Kitajima
European Respiratory Journal Sep 2014, 44 (Suppl 58) P1490;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Comparison of pulmonary inflammatory responses between intratracheal instillation and inhalation of nanoparticles
Hiroto Izumi, Yasuo Morimoto, Masanori Horie, Yukiko Yoshiura, Taisuke Tomonaga, Byeong-Woo Lee, Takami Okada, Takako Oyabu, Toshihiko Myojo, Manabu Shimada, Masaru Kubo, Kazuhiro Yamamoto, Shinichi Kitajima
European Respiratory Journal Sep 2014, 44 (Suppl 58) P1490;
Reddit logo Technorati logo Twitter logo Connotea logo Facebook logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Systemic inflammatory profile associated with exposure time to burning sugarcane
  • Clinico-radiological and functional assessment of respiratory symptomatics with either exposure to biomass fuel smoke or tobacco smoking
  • Burnt sugarcane harvesting is associated with short and long term alterations in systemic and pulmonary inflammatory markers
Show more 6.2 Occupational and Environmental Health

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society