Analysis of the level of carbon monoxide and carboxyhemoglobin teenagers consuming tobacco

Abstract

The search for effective markers for determining the level of nicotine metabolites in children consuming tobacco is important to determine preventive measures.

Aims and objectives: To assess the level of carbon monoxide (CO) and carboxyhemoglobin (HbCO) in exhaled air and urine cotinine indicators in adolescents consuming tobacco products.

Methods : A total of 73 adolescents aged 15-17 years ( Group 1 - 28 people smoking , Group 2 -16 smoking occasionally , 3 group of 29 people smoking. The levels of CO and HbCO in exhaled air was determined by using MicroCO (Handheld carbon monoxide monitors). Cotinine urinary metabolite of nicotine , was determined by test strips. Descriptive statistics for quantitative traits are presented by median and percentiles qualitative features percentage . Statistical significance of differences was determined by the Kruskal -Wallis test , Mann-Whitney , chi-square and Fisher's exact test . The force and direction determined by Spearman correlation .

Results: It was found that in group 1 level of CO and HbCO was 5.0 ( 3,0-9,5 ) and 0.8 ( 0,48-1,5 ) , in group 2 - 2.0 (2.0 -3.0 ) and 0.32 ( CI: 0.95 % :0,32 -0, 48), in group 3- 0.00 ( 0,00-0,5 ) and 0.00 ( 0,00-0 , 08 ) . In paired comparison with the help of method Mann Whitney revealed that P_{1, 2} = 0,12, P_{1, 3} <0,001, P_{2, 3} = 0.002 . A direct strong , statistically significant correlation between the level of CO in the exhaled air HbCO Group 1 (r = 1,00; p <0,01) and 2 (r = 0,924; p <0,01).

Conclusions : The level of HbCO and CO in exhaled air depends on the fact and extent of smoking adolescents and may be an important marker for determining the effectiveness of control measures and prevention.