Abstract
Background:Pneumonia is now the 3rd leading cause of death in Japan with the most aged population. It is vital to investigate epidemiology and aetiology of both community-acquired pneumonia (CAP), health care associated pneumonia (HCAP) for making rational public health policy. The APSG-Japan launched in September 2011 and presented a mid-term progress report last year. We now completed the two years of surveillance.
Objectives:1) to estimate adult CAP and HCAP incidence; 2) to describe aetiologic pathogens and serotype distribution of Streptococcus pneumoniae (S. pneumoniae) in Japan over two years.
Methods:A prospective multicenter surveillance was conducted targeting adult patients diagnosed as either CAP or HCAP at four community-based hospitals in Japan between September 2011 and January 2014. Clinical data and sputum specimens were collected and tested by conventional culture and in-house multiplex PCR detecting 12 respiratory viruses and 6 bacteria. S. pneumoniae positive samples were further examined for 50 serotypes by a novel nanofluidic PCR technique.
Results:The mean duration of survey was 23.8 months; the total number of actively enrolled cases was 3,556. 59% were male and the median age was 77 years. S. pneumonia (9%) and Heamophilus infulenzae (14%) were leading causative pathogens by conventional culture; multiplex PCR revealed a higher prevalence (23%) of S. pneumoniae, of which 53% were compatible with PCV 13 vaccine serotypes. Respiratory virus was frequently detected (28%).
Conclusion:The APSG-Japan has successfully accumulated the comprehensive information of CAP/HCAP in Japan. The results of final year progress will be presented.
- © 2014 ERS
