Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Subscriptions

Sputum interleukin (IL)-13 as a biomarker for the evaluation of asthma control

Zoi Tzilogianni, Petros Bakakos, Andriana I. Papaioannou, Anastasia Papaporfyriou, Georgios Hillas, Spyros Papiris, Nikolaos Koulouris, Stelios Loukides, Konstantinos Kostikas
European Respiratory Journal 2014 44: P1001; DOI:
Zoi Tzilogianni
11st Respiratory Medicine Department, University of Athens Medical School, Athens, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Petros Bakakos
11st Respiratory Medicine Department, University of Athens Medical School, Athens, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andriana I. Papaioannou
22nd Respiratory Medicine Department, University of Athens Medical School, Athens, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anastasia Papaporfyriou
11st Respiratory Medicine Department, University of Athens Medical School, Athens, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Georgios Hillas
11st Respiratory Medicine Department, University of Athens Medical School, Athens, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Spyros Papiris
22nd Respiratory Medicine Department, University of Athens Medical School, Athens, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nikolaos Koulouris
11st Respiratory Medicine Department, University of Athens Medical School, Athens, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stelios Loukides
22nd Respiratory Medicine Department, University of Athens Medical School, Athens, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Konstantinos Kostikas
22nd Respiratory Medicine Department, University of Athens Medical School, Athens, Greece
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Introduction: The management of patients with severe refractory asthma (SRA) is a difficult task that may benefit from the use of non-invasive assessment by biomarkers. Interleukin (IL)-13 is a cytokine with a central role in the TH2 response.

Objective: The assessment of IL-13 as a biomarker of asthma control in patients with SRA.

Methods: We recruited 170 patients (47 with SRA) from two University asthma clinics.Patients were submitted to pulmonary function testing, measurement of fractional exhaled nitric oxide (FeNO), and sputum induction with calculation of inflammatory cells and measurement of IL-13 in the supernatant. Asthma control test (ACT) was used for evaluation of asthma control (ACT values >19 identified well-controlled asthma). Severe refractory asthma was defined by the ATS criteria.

Results: IL-13 in sputum supernatant was increased in patients with SRA compared to patients with mild-to-moderate asthma [median (IQR): 156 (80-245) pg/mL vs. 78 (66-103) pg/mL, p<0.001], as well as in patients with persistent airflow obstruction [99 (71-199) pg/mL vs. 80 (66-105) pg/mL, p=0.0081]. IL-13 presented good diagnostic accuracy for the detection of not-well-controlled asthma in the whole group [specificity 94.2%, sensitivity 80.6% for a cut-off point of ≤156 pg/mL; area under the curve (AUC) 0.920]. The diagnostic accuracy of IL-13 was superior to FeNO or sputum eosinophils in patients with SRA (AUC 0.981 vs. 0.688 vs. 0.645 respectively; p<0.001).

Conclusions: IL-13 in induced sputum may represent a useful index of disease control in patients with SRA. The better diagnostic accuracy of IL-13, compared to FeNO and sputum eosinophils, indicates a central role of this mediator in SRA.

  • Biomarkers
  • Asthma - management
  • Inflammation
  • © 2014 ERS
Previous
Back to top
Vol 44 Issue Suppl 58 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Sputum interleukin (IL)-13 as a biomarker for the evaluation of asthma control
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Sputum interleukin (IL)-13 as a biomarker for the evaluation of asthma control
Zoi Tzilogianni, Petros Bakakos, Andriana I. Papaioannou, Anastasia Papaporfyriou, Georgios Hillas, Spyros Papiris, Nikolaos Koulouris, Stelios Loukides, Konstantinos Kostikas
European Respiratory Journal Sep 2014, 44 (Suppl 58) P1001;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Sputum interleukin (IL)-13 as a biomarker for the evaluation of asthma control
Zoi Tzilogianni, Petros Bakakos, Andriana I. Papaioannou, Anastasia Papaporfyriou, Georgios Hillas, Spyros Papiris, Nikolaos Koulouris, Stelios Loukides, Konstantinos Kostikas
European Respiratory Journal Sep 2014, 44 (Suppl 58) P1001;
Reddit logo Technorati logo Twitter logo Connotea logo Facebook logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Clinical differences between emphysematous and non-emphysematous COPD
  • Clinical and epidemiological assessment of the regional program of vaccination for pneumococcal infections
  • Risk for adverse outcomes in asthma: Assess to impress!
Show more 5.2 Monitoring Airway Disease

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society