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Aerobic exercise inhibits pseudomonas aeruginosa-induced acute lung injury in elderly mice

Flavia Regina Greiffo, Thomas Stravinskas Durigon, Juliana Moreno Guerra, Joao Paulo Pedroso, Danielle Silva Dias, Christiane Malfitano, Katia de Angelis, Flavio Aimbire, Nilsa Regina Damaceno-Rodrigues, Iris Takako Moribe, Edison Luiz Durigon, Regiane Albertini, Ana Paula Ligeiro de Oliveira, Rodolfo Paula Vieira
European Respiratory Journal 2014 44: 481; DOI:
Flavia Regina Greiffo
1Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University, Sao Paulo, Brazil
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Thomas Stravinskas Durigon
1Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University, Sao Paulo, Brazil
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Juliana Moreno Guerra
1Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University, Sao Paulo, Brazil
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Joao Paulo Pedroso
1Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University, Sao Paulo, Brazil
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Danielle Silva Dias
1Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University, Sao Paulo, Brazil
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Christiane Malfitano
1Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University, Sao Paulo, Brazil
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Katia de Angelis
1Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University, Sao Paulo, Brazil
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Flavio Aimbire
2Institute of Science and Technology, Federal University of Sao Paulo, Sao Jose dos Campos, Sao Paulo, Brazil
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Nilsa Regina Damaceno-Rodrigues
3School of Medicine (LIM 59), University of Sao Paulo, Sao Paulo, Brazil
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Iris Takako Moribe
4Department of Microbiology, University of Sao Paulo, Sao Paulo, Brazil
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Edison Luiz Durigon
4Department of Microbiology, University of Sao Paulo, Sao Paulo, Brazil
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Regiane Albertini
1Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University, Sao Paulo, Brazil
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Ana Paula Ligeiro de Oliveira
1Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University, Sao Paulo, Brazil
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Rodolfo Paula Vieira
1Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University, Sao Paulo, Brazil
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Abstract

The pseudomonas aeruginosa is a common opportunistic pathogen that can lead to death, especially to immunossupressed population, as elderly. Regular aerobic training (AT) improves lung response in pulmonary diseases and also the immune system. Therefore, this study investigated the possible protective effects of low intensity AT on the pulmonary inflammatory and immunological response in a model of acute lung injury induced by pseudomonas aeruginosa in elderly mice. The low intensity treadmill AT was performed during 4 weeks, 1 h/session, 4x/week in 24 weeks old C57Bl/6 male mice. Twenty-four hours after last AT session, mice were inoculated with 5 x 104 colony units of pseudomonas aeruginosa and were analyzed 24 hours after that. The results demonstrated that AT significantly reduced pseudomonas aeruginosa increased the numbers of total cells (p<0.01) and neutrophils (p<0.01) in the bronchoalveolar lavage (BAL) and the number of neutrophils in the lung parenchyma (p<0.01) when compared with pseudomonas group. The results also showed that AT reduced the levels of IL-1beta, IL-6, KC and TNF-alpha, while increased the levels of IL-10 in BAL (p<0.01) when compared with pseudomonas group. AT also increased the expression of IL-10 and reduced the expression of NF-kB in the lung when compared with pseudomonas group (p<0.01). In addtion, AT also increased the levels of catalase, glutatione peroxidase, superoxide dismutase and decreased the levels of lipoperoxidation in the lungs when compared with pseudomonas group (p<0.05). We conclude that AT inhibits acute lung injury induced by pseudomonas aeruginosa in ederly mice, through a IL-10/NF-kB/antioxidant-dependent mechanism.

  • Pneumonia
  • Bacteria
  • Animal models
  • © 2014 ERS
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Aerobic exercise inhibits pseudomonas aeruginosa-induced acute lung injury in elderly mice
Flavia Regina Greiffo, Thomas Stravinskas Durigon, Juliana Moreno Guerra, Joao Paulo Pedroso, Danielle Silva Dias, Christiane Malfitano, Katia de Angelis, Flavio Aimbire, Nilsa Regina Damaceno-Rodrigues, Iris Takako Moribe, Edison Luiz Durigon, Regiane Albertini, Ana Paula Ligeiro de Oliveira, Rodolfo Paula Vieira
European Respiratory Journal Sep 2014, 44 (Suppl 58) 481;

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Aerobic exercise inhibits pseudomonas aeruginosa-induced acute lung injury in elderly mice
Flavia Regina Greiffo, Thomas Stravinskas Durigon, Juliana Moreno Guerra, Joao Paulo Pedroso, Danielle Silva Dias, Christiane Malfitano, Katia de Angelis, Flavio Aimbire, Nilsa Regina Damaceno-Rodrigues, Iris Takako Moribe, Edison Luiz Durigon, Regiane Albertini, Ana Paula Ligeiro de Oliveira, Rodolfo Paula Vieira
European Respiratory Journal Sep 2014, 44 (Suppl 58) 481;
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