Abstract
Objective:
In this study we investigated the effect of low-intensity pulsed ultrasound (LIPUS) on fracture healing in rat ribs.
Methods:
72 male Wistar-Albino rats were randomly distributed in 3 equal groups, each including 24 subjects. To simulate a fracture; left thoracotomy was performed under general anaesthesia and a 0.5 cm segment was removed from the ribs. After 24 hours of surgery LIPUS began to be implemented according to the groups. Group 1 served as control for the observation of normal bone healing. LIPUS was applied at a doses of %20 (2 msn pulse-8 msn pause) 100 mW/cm2 and %50 (5 msn pulse – 5 msn pause) 200 mW/cm2 for 6 minutes per day respectively in group 2 and 3. Eight animals from each group were sacrificed at 2, 4 and 6 weeks for further assessment. We analysed histologic changes in the bone.
Results:
Although no statistical difference was noted for osteoblasts, osteoclasts, new bone formation and lymphocytes among all groups; histologic consolidation was significantly increased by LIPUS. In our study while LIPUS stimulates osteoblastic, osteoclastic and new bone formation, inhibits lymphocyte infiltration.
Conclusion:
In accordance with the literature, LIPUS either used in lower or higher doses stimulates the consolidation of rib fractures. The most prominent improvement was observed in 200 mW/cm2 group after long term follow-up. Accelerating the natural healing process in patients with rib fractures will be able to treat more effective, short and low cost treatment.
- © 2014 ERS
