Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Early life tobacco smoke exposure is associated with asthma and lung function deficits in adolescents

Xu Dai, S. Dharmage, Adrian Lowe, Katrina Allen, Paul Thomas, Jennifer Perret, David Hill, Clifford Hosking, John Hopper, Melanie Matheson, Cecilie Svanes, Liam Welsh, Michael Abramson, Caroline Lodge
European Respiratory Journal 2014 44: 1403; DOI:
Xu Dai
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Dharmage
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adrian Lowe
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
2Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katrina Allen
2Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
3Royal Children's Hospital, Royal Children's Hospital, Parkville, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul Thomas
4Inflammation and Infection Research Centre, University of New South Wales, Sydney, New South Wales, Australia
5Department of Respiratory Medicine, Prince of Wales Hospita, Randwick, New South Wales, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jennifer Perret
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Hill
2Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Clifford Hosking
9Department of Paediatrics, John Hunter Children's Hospital, New Lambton Newcastle, New South Wales, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John Hopper
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Melanie Matheson
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cecilie Svanes
6Bergen Respiratory Research Group, Institute of Medicine, University of Bergen, Bergen, Norway
7Dept Occupational Medicine, Haukeland University Hospital, Bergen, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Liam Welsh
10Department of Respiratory Medicine, Royal Childrens Hospital, Parkville, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Abramson
9Department of Paediatrics, John Hunter Children's Hospital, New Lambton Newcastle, New South Wales, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Caroline Lodge
1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Background: Parental smoking is associated with asthma and impaired lung function during early childhood. Less is known about the impact of early life smoke exposure on asthma, lung function and lung function growth into adolescence.

Objective: To determine the association between perinatal smoke exposure and lung function and asthma up to18 years.

Method: The Melbourne Atopy Cohort Study (MACS), a high-risk birth cohort (n= 620), recorded parental smoking at baseline and respiratory outcomes including spirometry at 12 and 18 years. Multiple logistic regression was used to analyse the associations between perinatal smoking and reported asthma at 12 (n=370) and 18 years (n=411). Multiple linear regression assessed the effect of perinatal smoking on lung function at 12 and 18 years and lung function growth between 12 and 18 years.

Results: At 18 years, girls exposed to parental smoking in the perinatal period had increased odds of asthma (OR: 3.45, 95%CI: 1.36, 8.77) and reduced: pre-bronchodilator FEV1 (decreased by 214, 95%CI: 39, 389 ml); FEV1/FVC ratio (deceased by 0.077, 95%CI: 0.017, 0.138); and MEF25-75 (reduced by 430, 95%CI: 61, 798 ml/s), as well as reduced post bronchodilator FEV1/FVC (decreased by 0.073, 95%CI: 0.018, 0.128). No associations seen for boys. Furthermore, impairment of lung function growth in pre-bronchodilator FEV1 between 12 and 18 years was associated with early life maternal smoking, (reduced by 261, 95%CI: 20, 502 ml) independent of gender.

Conclusion: Perinatal smoke exposure is associated with increased risk of asthma, reduced lung function and reduced lung function growth in adolescence. Adolescent girls appear to be more susceptible than boys.

  • Adolescents
  • Lung growth/development
  • Public health
  • © 2014 ERS
Previous
Back to top
Vol 44 Issue Suppl 58 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Early life tobacco smoke exposure is associated with asthma and lung function deficits in adolescents
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Early life tobacco smoke exposure is associated with asthma and lung function deficits in adolescents
Xu Dai, S. Dharmage, Adrian Lowe, Katrina Allen, Paul Thomas, Jennifer Perret, David Hill, Clifford Hosking, John Hopper, Melanie Matheson, Cecilie Svanes, Liam Welsh, Michael Abramson, Caroline Lodge
European Respiratory Journal Sep 2014, 44 (Suppl 58) 1403;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Early life tobacco smoke exposure is associated with asthma and lung function deficits in adolescents
Xu Dai, S. Dharmage, Adrian Lowe, Katrina Allen, Paul Thomas, Jennifer Perret, David Hill, Clifford Hosking, John Hopper, Melanie Matheson, Cecilie Svanes, Liam Welsh, Michael Abramson, Caroline Lodge
European Respiratory Journal Sep 2014, 44 (Suppl 58) 1403;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Characteristics of Iranian hookah users aged 15 years and older, primary report
  • Waterpipe tobacco smoking prevalence and its related factors among Iranian population
  • Smoking status at 18-19yo according age of first experimentation in Parisan schoolchildren
Show more 6.3 Tobacco, Smoking Control and Health Education

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society