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Medical nanoparticles for next generation drug delivery to the lungs

Sabine H. van Rijt, Thomas Bein, Silke Meiners
European Respiratory Journal 2014 44: 765-774; DOI: 10.1183/09031936.00212813
Sabine H. van Rijt
1Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany
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  • For correspondence: sabine.vanrijt@helmholtz-muenchen.de
Thomas Bein
2Dept of Chemistry, Center for NanoScience (CeNS), Ludwig-Maximilians University, Munich, Germany
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Silke Meiners
1Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany
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Abstract

Respiratory diseases are an increasing burden for the ageing population. Although our understanding of these diseases has improved significantly over the past decades, diagnostic and therapeutic options for treating lung diseases, such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and lung cancer, remain limited. Multidisciplinary approaches that bridge the gap between medicinal and materials sciences will likely contribute to promising new therapeutic and diagnostic solutions. One such multidisciplinary approach is the use of nanoparticles as carriers for the delivery of drugs. The advantages of using nanoparticles to deliver drugs include: increased drug concentration at the disease site; minimised drug degradation and loss; ease of creating inhalable formulations; and the possibility of specific cell targeting. This article gives a brief overview on the emerging field of nanocarriers as drug delivery vehicles for the treatment of lung diseases.

Abstract

This article provides an overview on the emerging field of nanocarriers as drug delivery vehicles for lung therapy http://ow.ly/vkNCx

Footnotes

  • Support statement: The Alexander von Humboldt foundation (Bonn, Germany) provided funding for S.H. van Rijt.

  • Conflict of interest: None declared.

  • Received December 6, 2013.
  • Accepted March 26, 2014.
  • ©ERS 2014
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European Respiratory Journal: 44 (3)
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Medical nanoparticles for next generation drug delivery to the lungs
Sabine H. van Rijt, Thomas Bein, Silke Meiners
European Respiratory Journal Sep 2014, 44 (3) 765-774; DOI: 10.1183/09031936.00212813

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Medical nanoparticles for next generation drug delivery to the lungs
Sabine H. van Rijt, Thomas Bein, Silke Meiners
European Respiratory Journal Sep 2014, 44 (3) 765-774; DOI: 10.1183/09031936.00212813
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