Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

Assessment of ventriculo-arterial interaction in pulmonary arterial hypertension using wave intensity analysis

Edmund M.T. Lau, David Abelson, Nathan Dwyer, Young Yu, Martin K. Ng, David S. Celermajer
European Respiratory Journal 2014 43: 1804-1807; DOI: 10.1183/09031936.00148313
Edmund M.T. Lau
1Sydney Medical School, University of Sydney, Camperdown
2Dept of Cardiology, Royal Prince Alfred Hospital, Camperdown
3Dept of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Abelson
2Dept of Cardiology, Royal Prince Alfred Hospital, Camperdown
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nathan Dwyer
4Dept of Cardiology, Royal Hobart Hospital, Hobart, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Young Yu
1Sydney Medical School, University of Sydney, Camperdown
2Dept of Cardiology, Royal Prince Alfred Hospital, Camperdown
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin K. Ng
1Sydney Medical School, University of Sydney, Camperdown
2Dept of Cardiology, Royal Prince Alfred Hospital, Camperdown
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David S. Celermajer
1Sydney Medical School, University of Sydney, Camperdown
2Dept of Cardiology, Royal Prince Alfred Hospital, Camperdown
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: david.celermajer@email.cs.nsw.gov.au
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

To the Editor:

Wave intensity analysis (WIA) is a recently described haemodynamic analysis methodology which enables assessment of ventriculo-arterial interactions via time-domain analysis of pressure and flow waveforms [1]. It enables quantification of wave energy, separation of waves into forward and backward components, and estimation of wave speed [2]. To date, WIA has not been applied to the pulmonary arterial circulation in humans. As WIA offers a potential novel approach for the study of pulmonary haemodynamics, the present study sought to evaluate the feasibility of invasive WIA of the pulmonary circulation during right heart catheterisation (RHC).

The study was approved by the institutional review board (Sydney Local Health District Ethics Review Committee (RPA Zone)) and consent was obtained from seven controls (mean±sd age 69±9 years, three females) and six patients (age 56±13 years, four females) with pulmonary arterial hypertension (PAH). Control subjects presented to the cardiac catheterisation laboratory for investigation of possible coronary artery disease. Following standard pulmonary haemodynamic measurements (including thermodilution cardiac output), a combined dual-tipped pressure and Doppler wire (ComboWire; Volcano, Rancho Cordova, CA, USA) was positioned distal to the origin of the right or left lower lobe pulmonary artery via a 6 Fr multipurpose catheter (Mach 1; Boston Scientific, Natick, MA, USA) under angiographic guidance. Pressure and flow measurements were acquired simultaneously at a sampling frequency of 1000 Hz, once stable signals were obtained.

Data were processed offline using customised MatLab software (MathWorks, Natick, MA, USA). Signals were ensemble-averaged with timing gated to the ECG R-wave and smoothed using a Savitzky–Golay filter [3]. Intrinsic hardware processing delays (between pressure and flow signals) were corrected by shifting signals to achieve a linear pressure–flow (P–U) relationship in early systole [4]. Wave speed (c) was derived from the P-U loop method [2]:Embedded Image

where dP/dU is the slope of P–U loop in early systole and ρ is density of blood, assumed to be 1060 kg·m−3.

WIA was performed as previously described [3] with separation of waves into forward (dI+) and backward (dI-) wave intensities:Embedded Image

Total wave energy for separated waves was calculated by integration of wave intensities over time. The magnitude of wave reflection (reflection coefficient) was calculated as the ratio of the total forward compression wave intensity to the total backward compression wave intensity [5]. The reflection distance (L) from the measurement site was estimated from the time delay between the peaks of the forward and backward compression waves, together with knowledge of wave speed:Embedded Image

Results are presented as mean±sd, unless otherwise stated. Differences between groups were compared using the Mann–Whitney U-test. Correlation was performed using Pearson’s test. Significance was inferred at a two-sided p<0.05.

The aetiologies of PAH were idiopathic PAH (n=3), scleroderma PAH (n=2) and portopulmonary hypertension (n=1). Haemodynamics in PAH group revealed a mean pulmonary arterial pressure (PAP) of 41±5 mmHg, pulmonary vascular resistance (PVR) of 6.3±4.4 Wood units and pulmonary capillary wedge pressure (PCWP) of 8±3 mmHg. Controls had normal pulmonary haemodynamics (mean PAP of 16±5 mmHg, PVR of 1.3±0.7 mmHg, and PCWP of 8±3 mmHg).

In both control and PAH groups, three dominant waves were consistently identified: 1) a forward compression wave (FCW) in early systole corresponding to ventricular ejection; 2) a forward expansion wave (FEW) in late systole representing ventricular relaxation and deceleration of blood flow; and 3) a backward compression wave (BCW) related to downstream reflection of the incident FCW (fig. 1).

Figure 1–
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 1–

Wave intensity analysis and corresponding ensemble-averaged pressure and flow velocity waveforms over a cardiac cycle. Positive wave intensity indicates forward travelling waves and negative intensity indicates backward travelling waves. The three dominant waves that were consistently identified included: 1) a forward compression wave (FCW), 2) forward expansion wave, and 3) backward compression wave (BCW). Black waves accelerate forward flow and white waves decelerate forward flow. Δt refers to the time delay between incident FCW and reflected BCW. a) Pulmonary arterial hypertension (PAH) subject with mean pulmonary arterial pressure (PAP) of 40 mmHg and pulmonary vascular resistance (PVR) of 6 Wood units. Wave intensity analysis revealed significant wave reflection (reflection coefficient 0.26) with BCW arriving during the FCW in mid-systole. Estimated wave speed was 5.8 m·s−1. b) Control subject with mean PAP of 14 mmHg and PVR of 0.9 Wood units. In contrast to the PAH subject, wave reflection was minimal (reflection coefficient 0.08) with the BCW arriving after the FCW. The estimated wave speed was 3.5 m·s−1.

PAH patients displayed an increase in the total intensity in all of the identified waves (total FCW of 164.5±39.7×102 W·m−2·s−1 versus 88.3±20.7×102 W·m−2·s−1 in controls; total FEW of 85.1±36.0×102 W·m−2·s−1 versus 32.5±13.7×102 W·m−2·s−1 in controls; all p<0.01), with the most notable difference being a five-fold increase in the total BCW wave intensity (total BCW of 56.9±14.6 W·m−2·s−1 versus 10.7±5.6 W·m−2·s−1 in controls; p<0.01). Importantly, the total BCW intensity was proportionally larger relative to the total FCW intensity in PAH patients, resulting in a higher reflection coefficient (0.35±0.05 versus 0.11±0.06; p<0.01). Wave speed was significantly faster in PAH patients (6.9±1.3 m·s−1 versus 3.8±1.0 m·s−1; p<0.01), leading to earlier arrival (45±20 ms versus 89±30 ms; p<0.01) of the reflected BCW in midsystole. The estimated reflection site in PAH patients was 15±5 cm downstream from the measurement site in the proximal lower lobe artery. Wave speed correlated significantly with pulmonary capacitance (r=0.7, p<0.01).

To the best of our knowledge, this is the first study to apply WIA for the evaluation of pulsatile wave travel in the human pulmonary arterial circulation. WIA was feasible during routine RHC using a commercially available dual-tippled pressure and Doppler wire, and revealed relevant pathophysiological changes in PAH subjects characterised by: 1) increased wave reflections due to distal closed-end reflection sites; 2) increased energies of travelling waves indicating increased right ventricular workload; and 3) higher wave speed due to arterial stiffening resulting in earlier arrival of large reflected waves, augmenting afterload unfavourably in the still-ejecting right ventricle. The potential appeal of WIA is that these pathophysiological changes can be quantified in an integrative time-domain approach.

Time-domain analysis of pulmonary artery waveforms using invasive high-fidelity measurements has previously been limited to pressure waveforms only [6]. It has been suggested that pulmonary artery pressure waveform analysis can assess the timing, extent and magnitude of wave reflections [7]. However, time-domain pressure waveform analysis is critically dependent on the accurate determination of the inflection point, which may not be identifiable in all patients [8] and may, thus, result in erroneous estimation of wave reflection indices [9]. By combining pressure and flow waveforms, WIA overcomes such limitations of isolated pulmonary artery pressure waveform analysis, and potentially provides an improved assessment of wave reflection. Furthermore, WIA enables determination of local wave speed, allowing estimation of reflection site distances. However, it is unknown, at present, whether WIA can discriminate differences in reflection sites in chronic thromboembolic pulmonary hypertension (CTEPH) versus PAH, and whether it can aid in the partitioning of predominantly proximal versus distal disease in CTEPH.

Pulmonary artery impedance analysis has been the traditional method used to fully characterise pulsatile right ventricular afterload [10, 11]. As the impedance spectrum is presented in the frequency-domain, interpretation is not straightforward and is unintuitive for most clinicians. WIA offers an alternate approach to impedance analysis, and it has been demonstrated that both impedance and WIA can provide similar results for the separation of forward and backward waveforms [12], with WIA having the distinct advantage of data presentation in the time-domain. However, impedance and WIA are not interchangeable in other aspects. WIA describes wave energy which is a function of both the pump and the vasculature, whereas impedance provides information regarding right ventricular afterload (or the arterial system).

Some methodological limitations need to be acknowledged. Obtaining high quality in vivo measurements was challenging and it was technically difficult to achieve a stable catheter position in the main pulmonary artery (the ideal anatomical position as the entire circulation is “seen”); therefore, the lower lobe vessels were studied. It is unknown whether WIA (or impedance) will differ between the upper or lower lobe pulmonary artery in healthy and PAH subjects in the supine posture, as we are not aware of any previous literature on this subject. Numbers of subjects were small in this preliminary study, but the differences between groups were very marked.

In conclusion, we demonstrate, in this preliminary “proof of principle” study, that WIA of the pulmonary circulation is feasible during RHC and may offer a novel time-domain based approach for the assessment of ventriculo-arterial interactions in pulmonary vascular disease. Further validation studies are required to determine whether parameters derived from WIA provide incremental clinical information, additional to conventional haemodynamics, regarding prognosis and response to therapy.

Footnotes

  • Support statement: National Health and Medical Research Council Project Grant 512404 and Royal Australasian College of Physicians Basser Scholarship.

  • Conflict of interest: None declared.

  • Received August 25, 2013.
  • Accepted December 3, 2013.
  • ©ERS 2014

References

  1. ↵
    1. Parker KH,
    2. Jones CJ
    . Forward and backward running waves in the arteries: analysis using the method of characteristics. J Biomech Eng 1990; 112: 322–326.
    OpenUrlCrossRefPubMedWeb of Science
  2. ↵
    1. Parker KH
    . An introduction to wave intensity analysis. Med Biol Eng Comput 2009; 47: 175–188.
    OpenUrlCrossRefPubMedWeb of Science
  3. ↵
    1. Davies JE,
    2. Whinnett ZI,
    3. Francis DP,
    4. et al
    . Evidence of a dominant backward-propagating “suction” wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy. Circulation 2006; 113: 1768–1778.
    OpenUrlAbstract/FREE Full Text
  4. ↵
    1. Dwyer N,
    2. Yong AC,
    3. Kilpatrick D
    . Variable open-end wave reflection in the pulmonary arteries of anesthetized sheep. J Physiol Sci 2012; 62: 21–28.
    OpenUrlCrossRefPubMed
  5. ↵
    1. Penny DJ,
    2. Mynard JP,
    3. Smolich JJ
    . Aortic wave intensity analysis of ventricular-vascular interaction during incremental dobutamine infusion in adult sheep. Am J Physiol Heart Circ Physiol 2008; 294: H481–H489.
    OpenUrlAbstract/FREE Full Text
  6. ↵
    1. Champion HC,
    2. Michelakis ED,
    3. Hassoun PM
    . Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications. Circulation 2009; 120: 992–1007.
    OpenUrlFREE Full Text
  7. ↵
    1. Nakayama Y,
    2. Nakanishi N,
    3. Hayashi T,
    4. et al
    . Pulmonary artery reflection for differentially diagnosing primary pulmonary hypertension and chronic pulmonary thromboembolism. J Am Coll Cardiol 2001; 38: 214–218.
    OpenUrlCrossRefPubMedWeb of Science
  8. ↵
    1. Castelain V,
    2. Hervé P,
    3. Lecarpentier Y,
    4. et al
    . Pulmonary artery pulse pressure and wave reflection in chronic pulmonary thromboembolism and primary pulmonary hypertension. J Am Coll Cardiol 2001; 37: 1085–1092.
    OpenUrlCrossRefPubMedWeb of Science
  9. ↵
    1. Hughes AD,
    2. Park C,
    3. Davies J,
    4. et al
    . Limitations of augmentation index in the assessment of wave reflection in normotensive healthy individuals. PLoS One 2013; 8: e59371.
    OpenUrlCrossRefPubMed
  10. ↵
    1. Huez S,
    2. Brimioulle S,
    3. Naeije R,
    4. et al
    . Feasibility of routine pulmonary arterial impedance measurements in pulmonary hypertension. Chest 2004; 125: 2121–2128.
    OpenUrlCrossRefPubMedWeb of Science
  11. ↵
    1. Murgo JP,
    2. Westerhof N
    . Input impedance of the pulmonary arterial system in normal man. Effects of respiration and comparison to systemic impedance. Circ Res 1984; 54: 666–673.
    OpenUrlAbstract/FREE Full Text
  12. ↵
    1. Hughes AD,
    2. Parker KH
    . Forward and backward waves in the arterial system: impedance or wave intensity analysis? Med Biol Eng Comput 2009; 47: 207–210.
    OpenUrlCrossRefPubMedWeb of Science
View Abstract
PreviousNext
Back to top
View this article with LENS
Vol 43 Issue 6 Table of Contents
European Respiratory Journal: 43 (6)
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Assessment of ventriculo-arterial interaction in pulmonary arterial hypertension using wave intensity analysis
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Assessment of ventriculo-arterial interaction in pulmonary arterial hypertension using wave intensity analysis
Edmund M.T. Lau, David Abelson, Nathan Dwyer, Young Yu, Martin K. Ng, David S. Celermajer
European Respiratory Journal Jun 2014, 43 (6) 1804-1807; DOI: 10.1183/09031936.00148313

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Assessment of ventriculo-arterial interaction in pulmonary arterial hypertension using wave intensity analysis
Edmund M.T. Lau, David Abelson, Nathan Dwyer, Young Yu, Martin K. Ng, David S. Celermajer
European Respiratory Journal Jun 2014, 43 (6) 1804-1807; DOI: 10.1183/09031936.00148313
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • CTEPH and totally implantable central venous access systems
  • Ivacaftor modifies cystic fibrosis neutrophil phenotype
  • Serum mitochondrial DNA predicts exacerbation and progression of IPF
Show more Agora

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2021 by the European Respiratory Society