Figures
- Figure 1–
Box and whisker plots of a) 6-min walk distance, b) mean pulmonary arterial pressure (PAP), c) cardiac index and d) pulmonary vascular resistance (PVR) at baseline, month 4 and the final follow-up visit (mean±sd follow-up time 32±19 months) after initiation of upfront epoprostenol, bosentan and sildenafil combination therapy (n=18). Squares represents the mean, boxes and diamonds represent the standard deviation, and whiskers represent the range.
Tables
- Table 1– Patients’ baseline characteristics
Subjects 19 Age years (range) 39.4±14.2 (18.1–63.1) Females 17 (89) Idiopathic/heritable/anorexigen-associated PAH 9/10/0 BMPR2 mutation carrier n/n tested (%) 10/13 (77) NYHA functional class III/IV 8 (42)/11 (58) 6-min walk distance m 215±174 Haemodynamics Right atrial pressure mmHg 12.2±5.2 Mean pulmonary arterial pressure mmHg 67.7±15.8 Pulmonary capillary wedge pressure mmHg 8.3±3.4 Cardiac output L·min−1 2.83±0.77 Cardiac index L·min−1·m−2 1.64±0.34 Pulmonary vascular resistance dyn·s·cm−5 1807±722 Mean blood pressure mmHg 91.7±12.2 Heart rate beats per min 92.3±10.7 Mixed venous oxygen saturation % 50.1±9.0 Data are presented as n, mean±sd or n (%), unless otherwise stated. PAH: pulmonary arterial hypertension; BMPR2: bone morphogenetic protein receptor type II; NYHA: New York Heart Association.
- Table 2– Functional class, 6-min walk distance (6MWD) and haemodynamics at the baseline, month 4 and final follow-up visits
Baseline Month 4 visit Final follow-up visit# NYHA FC I/II/III/IV n 0/0/8/10 1/16/1/0** 4/14/0/0** 6MWD m 227±171 463±94** 514±105**,¶ Haemodynamics RAP mmHg 11.9±5.2 4.9±4.9** 5.2±3.5** mPAP mmHg 65.8±13.7 45.7±14.0** 44.4±13.4** PCWP mmHg 8.4±3.5 6.7±3.2 7.9±2.8 Cardiac index L·min−1·m−2 1.66±0.35 3.49±0.69** 3.64±0.65** PVR dyn·s·cm−5 1718±627 564±260** 492±209** Mean BP mmHg 92.1±12.5 80.1±11.7** 84.9±19.4 HR beats per min 92.3±10.7 83.9±9.8** 79.9±13.4** SvO2 % 51.0±8.5 69.7±5.2** 72.2±4.0** Dose of epoprostenol achieved ng·kg−1·min−1 0 15.9±1.9 19.6±6.0 Data are presented as mean±sd unless otherwise stated. n=18. NYHA: New York Heart Association; FC: functional class; 6MWD: 6-minute walk distance; RAP: right atrial pressure; mPAP: mean pulmonary arterial pressure; PCWP: pulmonary capillary wedge pressure; PVR: pulmonary vascular resistance; BP: blood pressure; HR: heart rate; SvO2: mixed venous oxygen saturation. #: follow-up time 32±19 months. **: p<0.01 versus baseline; ¶: p<0.01 versus month 4 visit.
Disclosures
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