Subjects | 162 | 65 | 102 |
Demographics | | | |
Age years | 63.8±6.9 | 57.9±8.1* | 61.4±6.7*,# |
Male | 97 (59.9) | 31 (47.0)* | 47 (45.6)* |
Active smoker | 47 (29.0) | 0 | 0 |
Long-term oxygen therapy | 22 (13.6) | 0 | 0 |
Smoking history pack-years | 45.9±27.3 | 0±0 | 15.4±14.4* |
Body composition | | | |
Body mass index kg·m−2 | 25.0±4.1 | 26.7±3.9* | 27.6±3.8* |
Fat-free mass index kg·m−2 | 16.6±2.1 | 17.6±2.4* | 17.9±2.4* |
Bone mineral density T-score | -1.1±1.3 | | |
Pulmonary function | | | |
FEV1 L | 1.40±0.55 | 3.4±0.9* | 3.3±0.9* |
FEV1 % predicted | 51.4±17.4 | 119.6±14.8* | 119.2±17.7* |
FEV1/FVC % | 39.5±11.1 | 78.0±5.0* | 78.0±8.4* |
DLCO % predicted | 53.8±16.7 | 95.8±12.3* | 91.7±17.7* |
Blood gases | | |
PaCO2 kPa | 5.3±0.6 |
PaO2 kPa | 9.5±1.1 |
Oxygen saturation % | 94.4±7.6 |
Functional outcome | |
6MWD m | 475±108 |
CWRT time s | 359±284 |
Leg press weight kg | 101±47 |
mMRC grade | 2.1±1.1 |
SGRQ points | 51.6±18.4 |
Charlson comorbidity index | 1.57±0.89 |
Myocardial infarction | 16 (9.9) |
Heart failure | 5 (3.1) |
Peripheral arterial disease | 30 (18.5) |
Cerebrovascular disease | 14 (8.6) |
Any cardiovascular disease | 50 (30.9) |
Diabetes | 7 (4.3) |
Clinical chemistry | |
Triglycerides mmol·L−1 | 1.5±0.7 |
Low-density lipoprotein mmol·L−1 | 2.9±1.0 |
High-density lipoprotein mmol·L−1 | 1.7±0.5 |
Glucose mmol·L−1 | 5.7±0.7 |
Creatinine | 87.5±22.6 |
eGFR mL·min−1 | 75.9±21.5 |
Systemic inflammatory markers | |
C-reactive protein mg·L−1 | 4.6±6.1 |
Interleukin-6 pg·mL−1 | 3.3±4.5 |
Interleukin-8 pg·mL−1 | 13.0±5.3 |
sTNFR1 pg·mL−1 | 2186±771 |
sTNFR2 pg·mL−1 | 3714±1435 |
Leukocytes 109 per L | 7.5±2.0 |