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emPHasis-10: development of a health-related quality of life measure in pulmonary hypertension

Janelle Yorke, Paul Corris, Sean Gaine, J. Simon R. Gibbs, David G. Kiely, Carl Harries, Val Pollock, Iain Armstrong
European Respiratory Journal 2014 43: 1106-1113; DOI: 10.1183/09031936.00127113
Janelle Yorke
1School of Nursing, Midwifery and Social Work, University of Manchester, Manchester
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  • For correspondence: Janelle.Yorke@manchester.ac.uk
Paul Corris
2Dept of Respiratory Medicine, Freeman Hospital, Newcastle upon Tyne
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Sean Gaine
3Pulmonary Hypertension Unit, Mater Misericordiae University Hospital, Dublin, Ireland
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J. Simon R. Gibbs
4National Heart and Lung Institute, Imperial College London, London
5Pulmonary Hypertension Service, Hammersmith Hospital, London
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David G. Kiely
6Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield
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Carl Harries
7Pulmonary Hypertension Unit, Royal Brompton and Harefield Foundation NHS Trust, London
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Val Pollock
8Scottish Vascular Unit, Golden Jubilee National Hospital, Glasgow
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Iain Armstrong
6Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield
9Pulmonary Hypertension Association UK, Rotherham, UK
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Abstract

The aim of this study was to develop a measure of the impact of pulmonary hypertension (PH) on health-related quality of life (HRQoL) as there is a need for a short, validated instrument that can be used in routine clinical practice.

Interviews were conducted with 30 PH patients to derive 32 statements, which were presented as a semantic differential six-point scale (0–5), with contrasting adjectives at each end. This item list was completed by patients attending PH clinics across the UK and Ireland. Rasch analysis was applied to identify items fitting a uni-dimensional model.

226 patients (mean age 55.6±14 years; 70% female) with PH (82% had pulmonary arterial hypertension) completed the study questionnaires. 10 of the 32 items demonstrated fit to the Rasch model (Chi-squared 16; p>0.05) and generated the emPHasis-10 questionnaire. Test–retest (intraclass correlation coefficient 0.95, n=33) and internal consistency (Chronbach’s α=0.9) were strong. emPHasis-10 scores correlated consistently with other relevant measures and discriminated subgroups of patients stratified by World Health Organization functional class (ANOVA F=1.73; p<0.001).

The emPHasis-10 is a short questionnaire for assessing HRQoL in pulmonary arterial hypertension. It has excellent measurement properties and is sensitive to differences in relevant clinical parameters. It is freely available for clinical and academic use.

Abstract

emPHasis-10 is a short, valid tool for routine assessment of health-related quality of life in pulmonary hypertension http://ow.ly/qv75v

Footnotes

  • For editorial comments see page 960.

  • This article has supplementary material available from www.erj.ersjournals.com

  • Support statement: This study was funded by the Pulmonary Hypertension Association UK (Rotherham, UK).

  • Conflict of interest: Disclosures can be found alongside the online version of this article at www.erj.ersjournals.com

  • Received July 24, 2013.
  • Accepted October 20, 2013.
  • ©ERS 2014

ERJ Open articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 3.0.

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emPHasis-10: development of a health-related quality of life measure in pulmonary hypertension
Janelle Yorke, Paul Corris, Sean Gaine, J. Simon R. Gibbs, David G. Kiely, Carl Harries, Val Pollock, Iain Armstrong
European Respiratory Journal Apr 2014, 43 (4) 1106-1113; DOI: 10.1183/09031936.00127113

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emPHasis-10: development of a health-related quality of life measure in pulmonary hypertension
Janelle Yorke, Paul Corris, Sean Gaine, J. Simon R. Gibbs, David G. Kiely, Carl Harries, Val Pollock, Iain Armstrong
European Respiratory Journal Apr 2014, 43 (4) 1106-1113; DOI: 10.1183/09031936.00127113
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