Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

LSC 2013 abstract - Peripheral blood neutrophil chemotaxis and apoptosis in patients with allergic asthma challenged with dermatophagoides pteronyssinus

Simona Lavinskiene, Ieva Bajoriuniene, Jolanta Jeroch, Kestutis Malakauskas, Raimundas Sakalauskas
European Respiratory Journal 2013 42: PP152; DOI:
Simona Lavinskiene
1Pulmonology and Immunology, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ieva Bajoriuniene
1Pulmonology and Immunology, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jolanta Jeroch
1Pulmonology and Immunology, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kestutis Malakauskas
1Pulmonology and Immunology, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raimundas Sakalauskas
1Pulmonology and Immunology, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Background: Recent investigations suggest that neutrophils may play an important role in the allergen-induced inflammation in asthma [Monteseirin J., 2009; Kampe M. et al. 2011].

Aim: To analyze the changes of peripheral blood neutrophil chemotaxis and apoptosis in patients with allergic asthma after bronchial allergen challenge with Dermatophagoides pteronyssinus.

Methods: Thirty patients with allergic asthma (AA) and sensitized to D.pteronyssinus were enrolled into the study. They were compared with 30 patients with allergic rhinitis (AR), sensitized to D.pteronyssinus and 20 healthy individuals (HI). All subjects underwent bronchial challenge with D.pteronyssinus. Peripheral blood collection and neutrophil isolation were performed 24 h before as well as 7 h and 24 h after bronchial challenge. Neutrophil chemotaxis was evaluated after stimulation with IL-8. Annexin-V FITC was used to detect apoptotic neutrophils. Neutrophil chemotaxis and apoptosis were analyzed by flow cytometer.

Results: Before, 7 h and 24 h after the bronchial allergen challenge, neutrophil chemotaxis was greater in patients with AA compared with those with AR and HI as well. The apoptotic activity of neutrophils was lower before, 7 h as well as 24 h after the challenge in patients with AA than in HI. Meanwhile, differences on neutrophil apoptosis between AA and AR patients was found only 7 h and 24 h after the challenge.

Conclusions: Inhaled D.pteronyssinus activates peripheral blood neutrophil chemotaxis and reduces apoptosis in sensitized patients, that demonstrates enhancement of systemic inflammation.

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

  • © 2013 ERS
Previous
Back to top
Vol 42 Issue Suppl 57 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
LSC 2013 abstract - Peripheral blood neutrophil chemotaxis and apoptosis in patients with allergic asthma challenged with dermatophagoides pteronyssinus
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
LSC 2013 abstract - Peripheral blood neutrophil chemotaxis and apoptosis in patients with allergic asthma challenged with dermatophagoides pteronyssinus
Simona Lavinskiene, Ieva Bajoriuniene, Jolanta Jeroch, Kestutis Malakauskas, Raimundas Sakalauskas
European Respiratory Journal Sep 2013, 42 (Suppl 57) PP152;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
LSC 2013 abstract - Peripheral blood neutrophil chemotaxis and apoptosis in patients with allergic asthma challenged with dermatophagoides pteronyssinus
Simona Lavinskiene, Ieva Bajoriuniene, Jolanta Jeroch, Kestutis Malakauskas, Raimundas Sakalauskas
European Respiratory Journal Sep 2013, 42 (Suppl 57) PP152;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • LATE-BREAKING ABSTRACT: Single inhaler triple therapy (ICS/LAMA/LABA) in patients with advanced COPD: Results of the FULFIL trial
  • LATE-BREAKING ABSTRACT: Which predictors in COPD patients with the frequent exacerbator phenotype predict the treatment response to maintenance therapy with azithromycin?
  • LATE-BREAKING ABSTRACT: Intra-day symptoms fluctuations: STORICO, observational study on the characterization of 24-hour symptoms in COPD patients
Show more 1.1 Clinical Problems

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2022 by the European Respiratory Society