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LSC 2013 abstract - Th17 response to inhaled dermatophagoides pteronyssinus is related to late-phase airway and systemic inflammation in patients with allergic asthma

Ieva Bajoriuniene, Simona Lavinskiene, Edita Gasiuniene, Kestutis Malakauskas, Raimundas Sakalauskas
European Respiratory Journal 2013 42: PP101; DOI:
Ieva Bajoriuniene
1Department of Pulmonology and Immunology, Lithuanian University of Health Sciences, Kaunas, Lithuania
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Simona Lavinskiene
1Department of Pulmonology and Immunology, Lithuanian University of Health Sciences, Kaunas, Lithuania
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Edita Gasiuniene
1Department of Pulmonology and Immunology, Lithuanian University of Health Sciences, Kaunas, Lithuania
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Kestutis Malakauskas
1Department of Pulmonology and Immunology, Lithuanian University of Health Sciences, Kaunas, Lithuania
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Raimundas Sakalauskas
1Department of Pulmonology and Immunology, Lithuanian University of Health Sciences, Kaunas, Lithuania
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Abstract

Background: Th17 response may have played a role in the development of the late-phase allergen-induced inflammation in allergic asthma.

Aim: We investigated Th17 response to inhaledD. pteronyssinus(DP) to establish the importance of these cells in late-phase airway and systemic inflammation in patients with allergic asthma (AA).

Methods: A total of 36 subjects were examined: 15 patients with AA who developed early (EAR, n=7) and dual asthmatic reaction (DAR, n=8) after bronchial challenge with DP,13 patients with allergic rhinitis (AR) and 8 healthy subjects (HS). Peripheral blood (PB) and sputum collection were performed 24 h before as well as 7 h and 24 h after challenge. PB Th17 cells was analyzed by FACS and IL-17 levels were determined by ELISA.

Results:

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Conclusions: The percentage of PB Th17 cells, serum and sputum IL-17 levels were found to be highest in AA patients with DAR. Enhanced Th17 cell response to inhaled DP shows an important role of these cells in the development of late-phase allergen-induced airway and systemic inflammation in patients with AA.

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LSC 2013 abstract - Th17 response to inhaled dermatophagoides pteronyssinus is related to late-phase airway and systemic inflammation in patients with allergic asthma
Ieva Bajoriuniene, Simona Lavinskiene, Edita Gasiuniene, Kestutis Malakauskas, Raimundas Sakalauskas
European Respiratory Journal Sep 2013, 42 (Suppl 57) PP101;

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LSC 2013 abstract - Th17 response to inhaled dermatophagoides pteronyssinus is related to late-phase airway and systemic inflammation in patients with allergic asthma
Ieva Bajoriuniene, Simona Lavinskiene, Edita Gasiuniene, Kestutis Malakauskas, Raimundas Sakalauskas
European Respiratory Journal Sep 2013, 42 (Suppl 57) PP101;
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