Abstract
Background: Th17 response may have played a role in the development of the late-phase allergen-induced inflammation in allergic asthma.
Aim: We investigated Th17 response to inhaledD. pteronyssinus(DP) to establish the importance of these cells in late-phase airway and systemic inflammation in patients with allergic asthma (AA).
Methods: A total of 36 subjects were examined: 15 patients with AA who developed early (EAR, n=7) and dual asthmatic reaction (DAR, n=8) after bronchial challenge with DP,13 patients with allergic rhinitis (AR) and 8 healthy subjects (HS). Peripheral blood (PB) and sputum collection were performed 24 h before as well as 7 h and 24 h after challenge. PB Th17 cells was analyzed by FACS and IL-17 levels were determined by ELISA.
Results:
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Fig.2
Conclusions: The percentage of PB Th17 cells, serum and sputum IL-17 levels were found to be highest in AA patients with DAR. Enhanced Th17 cell response to inhaled DP shows an important role of these cells in the development of late-phase allergen-induced airway and systemic inflammation in patients with AA.
- © 2013 ERS
