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CXCR1 is dispensable for allergy-driven airway leukocyte recruitment in vivo

Melanie Carevic, Martina Bakele, Sandra Beer-Hammer, Lauren Mays, Dominik Bloes, Peter Gierschik, Stella Autenrieth, Michael Kormann, Barbara Moepps, Dominik Hartl
European Respiratory Journal 2013 42: P4740; DOI:
Melanie Carevic
1Pediatrics, University of Tübingen, Tübingen, Germany
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Martina Bakele
1Pediatrics, University of Tübingen, Tübingen, Germany
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Sandra Beer-Hammer
1Pediatrics, University of Tübingen, Tübingen, Germany
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Lauren Mays
1Pediatrics, University of Tübingen, Tübingen, Germany
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Dominik Bloes
1Pediatrics, University of Tübingen, Tübingen, Germany
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Peter Gierschik
1Pediatrics, University of Tübingen, Tübingen, Germany
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Stella Autenrieth
1Pediatrics, University of Tübingen, Tübingen, Germany
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Michael Kormann
1Pediatrics, University of Tübingen, Tübingen, Germany
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Barbara Moepps
1Pediatrics, University of Tübingen, Tübingen, Germany
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Dominik Hartl
1Pediatrics, University of Tübingen, Tübingen, Germany
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Abstract

Chemokines recruit inflammatory cells to sites of inflammation. Human CXCL8 (Interleukin 8) represents the prototypical chemokine for neutrophil migration by binding to the G-protein coupled chemokine receptors CXCR1 (IL-8RA, CD181) and CXCR2 (IL-8RB, CD182). While the role of CXCR2 has been investigated in detail by genetic deletion or pharmacologic inhibition, the distinct contribution of CXCR1 remains incompletely understood. The murine homologue of human CXCR1 has recently been identified. Here we studied the role of CXCR1 in leukocyte recruitment by using recently generated CXCR1 knock-out mice and in vivo models of airway inflammation (ovalbumin and house dust mite models of allergic asthma), infection-triggered cell recruitment and chemotaxis. In contrast to human CXCR1, murine CXCR1 was dispensable for the recruitment of neutrophils, monocytes, dendritic cells or T cells in models of allergic or bacterial inflammation. These studies demonstrate that CXCR1 is dispensable for allergy-driven airway leukocyte recruitment and inflammatory cell migration in vivo. The functional role of murine CXCR1 in cell recruitment and pulmonary inflammation remains to be solved in future studies.

  • Cell biology
  • Animal models
  • Immunology
  • © 2013 ERS
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CXCR1 is dispensable for allergy-driven airway leukocyte recruitment in vivo
Melanie Carevic, Martina Bakele, Sandra Beer-Hammer, Lauren Mays, Dominik Bloes, Peter Gierschik, Stella Autenrieth, Michael Kormann, Barbara Moepps, Dominik Hartl
European Respiratory Journal Sep 2013, 42 (Suppl 57) P4740;

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CXCR1 is dispensable for allergy-driven airway leukocyte recruitment in vivo
Melanie Carevic, Martina Bakele, Sandra Beer-Hammer, Lauren Mays, Dominik Bloes, Peter Gierschik, Stella Autenrieth, Michael Kormann, Barbara Moepps, Dominik Hartl
European Respiratory Journal Sep 2013, 42 (Suppl 57) P4740;
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