Abstract
Introduction
Alpha-1-antitrypsin deficiency (AATD) is a recognised susceptibility factor for the development of COPD although the natural history in the absence of smoking is poorly documented.
Method
We assessed the FEV1 (% predicted) and Kco (% predicted) in 202 never smokers referred to the UK AAT database and compared the data to their age at assessment for individuals < and ≥ 45 years age.
Results
The patients age ranged from 16-76 years and a significant negative correlation was present for FEV1 vs. age (r=0.422; p<0.0001) and Kco vs. age (r=0.474; p<0.0001). Under the age of 45 (n=59) the average FEV1 was 106.1% predicted (SE 2.7) and was below the normal range in 6. The Kco was 92.4% predicted (± 1.9) and below the normal range in 10.
Over 45 years age (n=143) the average FEV1 was 76.7 ± 2.7% predicted and Kco was 69.4 ± 1.7% predicted. However 49.7% and 38.0% of patients still had FEV1 and Kco respectively within the normal range.
Conclusion
Although AATD influences lung function independently of smoking there is a wide range of impact on physiology which remains normal in many patients suggesting other epigenetic influences.
This poster was funded by an unlimited educational grant from Grifols.
- © 2013 ERS
