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EGFR frequency and response to chemotherapy in a Brazilian NSCLC population

Helen Naemi Honma, Maurício de Toledo Leme, Eduardo Mello De Capitani, Maurício Wesley Perroud, Aristóteles de Souza Barbeiro, Ana Paula Salles Perroud, Ivan Felizardo Toro, Ricardo Kalaf Mussi, José Cláudio Seabra, José Vassallo, André Morcillo, Daniel Botelho Costa, Lair Zambon
European Respiratory Journal 2013 42: P4496; DOI:
Helen Naemi Honma
1Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil
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Maurício de Toledo Leme
1Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil
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Eduardo Mello De Capitani
1Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil
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Maurício Wesley Perroud
1Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil
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Aristóteles de Souza Barbeiro
1Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil
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Ana Paula Salles Perroud
1Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil
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Ivan Felizardo Toro
2Surgery, State University of Campinas, Campinas, São Paulo, Brazil
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Ricardo Kalaf Mussi
2Surgery, State University of Campinas, Campinas, São Paulo, Brazil
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José Cláudio Seabra
2Surgery, State University of Campinas, Campinas, São Paulo, Brazil
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José Vassallo
3Pathology, State University of Campinas, Campinas, São Paulo, Brazil
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André Morcillo
4Pediatrics, State University of Campinas, Campinas, São Paulo, Brazil
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Daniel Botelho Costa
5Hematology/Oncology, Beth Israel Deaconess Medial Center, Harvard Medical School, Boston, MA, United States
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Lair Zambon
1Internal Medicine, State University of Campinas, Campinas, São Paulo, Brazil
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Abstract

Introduction: Epidermal growth factor receptor (EGFR) is one of the major molecular targets for cancer diagnosis and therapy.

Aim: The purpose of this study was to estimate and compare the frequency of EGFR in a Brazilian NSCLC population, and to associate them with clinical outcome, and response to platinum derivatives and paclitaxel chemotherapy.

Materials and Methods: 124 biopsies of NSCLC patients were collected and analyzed by PCR-SSCP (used as screening for mutation in the EGFR gene, exons 18-21). The samples were further cloned and sequenced to confirm the mutation.

Results: Out of 124 patients, only 64 had clinical conditions for chemotherapy Among them, 35 patients were diagnosed with adenocarcinoma. The frequency of mutation in the EGFR gene in the 124 patients was 4.83%. Among the 64 patients who responded, or not, to QTX the frequency was 9.3%, and among the adenocarcinoma patients, 17.1%. Multivariate logistic regression analysis confirmed that the chance of patients having a mutation in the EGFR gene and having a positive QTX response is 14 times higher than in patients without this mutation [OR= 14.38; 95% CI= 1.41 - 146.68; p= 0.024]. Patients with ECOG 2 showed bad response to QTX [OR= 3.9; 95% CI= 1.0 - 3.93; p= 0.034].

Conclusions: A more personalizing patient-oriented therapy is a promising approach for selecting the most appropriate therapies aiming to optimize effectiveness, minimize toxicity, and reduce costs, increasing survival and quality of life. However, more studies are needed to confirm these results, and to define how the drugs sequence should be used in this group of patients.

  • Lung cancer / Oncology
  • Mutation analysis
  • © 2013 ERS
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EGFR frequency and response to chemotherapy in a Brazilian NSCLC population
Helen Naemi Honma, Maurício de Toledo Leme, Eduardo Mello De Capitani, Maurício Wesley Perroud, Aristóteles de Souza Barbeiro, Ana Paula Salles Perroud, Ivan Felizardo Toro, Ricardo Kalaf Mussi, José Cláudio Seabra, José Vassallo, André Morcillo, Daniel Botelho Costa, Lair Zambon
European Respiratory Journal Sep 2013, 42 (Suppl 57) P4496;

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EGFR frequency and response to chemotherapy in a Brazilian NSCLC population
Helen Naemi Honma, Maurício de Toledo Leme, Eduardo Mello De Capitani, Maurício Wesley Perroud, Aristóteles de Souza Barbeiro, Ana Paula Salles Perroud, Ivan Felizardo Toro, Ricardo Kalaf Mussi, José Cláudio Seabra, José Vassallo, André Morcillo, Daniel Botelho Costa, Lair Zambon
European Respiratory Journal Sep 2013, 42 (Suppl 57) P4496;
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