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Pulmonary infections as a result of stroke induced immunodepression

Claudia Dames, Levent Akyüz, Odilo Engel, Katarzyna Winek, Hans-Dieter Volk, Andreas Meisel, Christian Meisel
European Respiratory Journal 2013 42: P4395; DOI:
Claudia Dames
1Institute for Medical Immunology, Charité Universitätsmedizin, Berlin, Germany
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Levent Akyüz
1Institute for Medical Immunology, Charité Universitätsmedizin, Berlin, Germany
2Berlin-Brandenburg Center for Regenerative Therapies, Charité Universitätsmedizin, Berlin, Germany
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Odilo Engel
3Department of Experimental Neurology, Charité Universitätsmedizin, Berlin, Germany
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Katarzyna Winek
3Department of Experimental Neurology, Charité Universitätsmedizin, Berlin, Germany
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Hans-Dieter Volk
1Institute for Medical Immunology, Charité Universitätsmedizin, Berlin, Germany
2Berlin-Brandenburg Center for Regenerative Therapies, Charité Universitätsmedizin, Berlin, Germany
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Andreas Meisel
3Department of Experimental Neurology, Charité Universitätsmedizin, Berlin, Germany
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Christian Meisel
1Institute for Medical Immunology, Charité Universitätsmedizin, Berlin, Germany
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Abstract

Pulmonary infection is a highly relevant complication and leading cause of death in patients with acute CNS injury. The high incidence of pneumonia in these patients is likely to be the result of temporary stroke induced immunodepression. We here analysed changes in cellularity and function of lung immune and epithelial cells by FACS and ex vivo stimulation at different time points after experimental stroke in mice. In addition, we monitored pulmonary host responses in vivo during the course of pneumococcal pneumonia by analyzing cellular changes, cytokine/ chemokine levels and barrier function in lungs of stroke mice and sham controls.

Analysis of cellularity at different time points after stroke showed a loss of interstitial macrophages within the first day after stroke as well as decreased numbers of dendritic cells and lymphocytes in lung. Functional analysis of immune cells indicates an impaired cytokine production in lung cells after ex vivo TLR stimulation. In a model of induced pneumonia we analysed the in vivo host response to Streptococcus pneumonia after stroke. Our data suggest that pulmonary phagocytes in stroke mice are not able to clear the bacteria. It seems that this results in a prolonged hyper-inflammatory response with increased cytokine levels in lungs followed by a disruption of the epithelial cell barrier function.

The correlation between impaired activation of pulmonary antimicrobial immune responses and development of infectious complications is still incompletely understood. A detailed knowledge of leukocyte recruitment and defects in anti-bacterial defences may lead to new therapeutic strategies such as local immunostimulatory treatment to prevent infections and improve outcome.

  • Immunology
  • Pneumonia
  • Animal models
  • © 2013 ERS
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Pulmonary infections as a result of stroke induced immunodepression
Claudia Dames, Levent Akyüz, Odilo Engel, Katarzyna Winek, Hans-Dieter Volk, Andreas Meisel, Christian Meisel
European Respiratory Journal Sep 2013, 42 (Suppl 57) P4395;

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Pulmonary infections as a result of stroke induced immunodepression
Claudia Dames, Levent Akyüz, Odilo Engel, Katarzyna Winek, Hans-Dieter Volk, Andreas Meisel, Christian Meisel
European Respiratory Journal Sep 2013, 42 (Suppl 57) P4395;
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