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Effect of 3-month CPAP treatment on blood pressure and serum aldosterone concentration in patients with resistant hypertension

Patricia Lloberes, Gabriel Sampol, Eugenia Espinel, Alfons Segarra, M. Ferrer, Odile Romero, Maria Jose Jurado, M. Antonia Ramon, Dolores Untoria, Miguel Angel Martinez Garcia
European Respiratory Journal 2013 42: P307; DOI:
Patricia Lloberes
1Pneumology-Sleep Unit, Hospital Universitari Vall D'Hebron, Barcelona, Spain
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Gabriel Sampol
1Pneumology-Sleep Unit, Hospital Universitari Vall D'Hebron, Barcelona, Spain
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Eugenia Espinel
2Nephrology, Hospital Universitari Vall D'Hebron, Barcelona, Spain
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Alfons Segarra
2Nephrology, Hospital Universitari Vall D'Hebron, Barcelona, Spain
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M. Ferrer
4Biochemistry, Hospital Universitari Vall D'Hebron, Barcelona, Spain
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Odile Romero
3Neurophysiology-Sleep Unit, Hospital Universitari Vall D'Hebron, Barcelona, Spain
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Maria Jose Jurado
3Neurophysiology-Sleep Unit, Hospital Universitari Vall D'Hebron, Barcelona, Spain
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M. Antonia Ramon
1Pneumology-Sleep Unit, Hospital Universitari Vall D'Hebron, Barcelona, Spain
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Dolores Untoria
1Pneumology-Sleep Unit, Hospital Universitari Vall D'Hebron, Barcelona, Spain
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Miguel Angel Martinez Garcia
5Pneumology, Hospital La Fe, Valencia, Spain
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Abstract

Introduction: The role of the renin-angiotensin-aldosterone system (RAAS) on the association obstructive sleep apnea (OSA) and resistant hypertension (RH) is unclear. Aim: To analyze the effect of CPAP on 24-h blood pressure monitoring (ABPM) and on serum aldosterone in RH patients. Methods: 102 patients with an OSA15 and office-RH were randomized to CPAP (n=50) or to conventional treatment (n=52) for 3 months. 24-h ABPM and serum aldosterone were measured. 78 patients completed the follow-up (36 CPAP, 42 conventional treatment). Results: 66.7% were male, aged 58.27±9.3yrs and AHI 50.1±21.6, without significant differences between both groups. Serum aldosterone and AHI correlated significantly in patients with ABPM-confirmed RH (r= 0.25, p=0.02). CPAP achieved a significant decrease in serum aldosterone and 24-h BP decreased especially in those with ABPM-confirmed RH.

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Effects of 3-month treatment on 24-h BP and serum aldosterone in patients with ABPM-confirmed resistant hypertension, randomized to conventional treatment or to CPAP

Conclusion: The association between OSA and RH could be mediated at least in part by an effect on the RAAS.

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Effect of 3-month CPAP treatment on blood pressure and serum aldosterone concentration in patients with resistant hypertension
Patricia Lloberes, Gabriel Sampol, Eugenia Espinel, Alfons Segarra, M. Ferrer, Odile Romero, Maria Jose Jurado, M. Antonia Ramon, Dolores Untoria, Miguel Angel Martinez Garcia
European Respiratory Journal Sep 2013, 42 (Suppl 57) P307;

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Effect of 3-month CPAP treatment on blood pressure and serum aldosterone concentration in patients with resistant hypertension
Patricia Lloberes, Gabriel Sampol, Eugenia Espinel, Alfons Segarra, M. Ferrer, Odile Romero, Maria Jose Jurado, M. Antonia Ramon, Dolores Untoria, Miguel Angel Martinez Garcia
European Respiratory Journal Sep 2013, 42 (Suppl 57) P307;
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More in this TOC Section

  • Comparison of peri-pharyngeal muscle recruitment during upper airway obstruction in patients with OSA and healthy subjects during wakefulness and sleep
  • Telemetrically triggered interventions in the first month of cpap treatment - A prospective, randomized controlled intervention trial in patients with a new diagnosis of obstructive sleep apnea syndrome
  • Home telemonitoring and adjustement of CPAP settings in patients with sleep apnea
Show more 4.2 Sleep and Control of Breathing

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