Abstract
Back ground
HAP is the most commonly – acquired infection in icu patients and related to a high mortality rate.
The detection of the most common causative microorganism, are imperative for guiding an initial empiric therapy in pneumonia
Methods
All Patients were Studied Prospectively for the occurrence of Pneumonia.
Those were the inclusion criteria in terms of APACHE II, CPIS, outcome, therapy were investigated.
Antimicrobial Susceptibility test were determined by disk diffusion method and dilution medium (the MIC) according to CLSI guideline on the ETA and BAL sampling.
Results
Incidence of nosocomial pneumonia was 11.5%, including 91. 4% VAP and 8,6% Non – Vap: VAP also includes 80% early – onset and 20% Late – onset. The. The most common microorganisms isolated was Acinetobacter SPP 22% and Staphylococcus aureus (14.6%), respectively. 30% of Acinetobacter SPP were resistant to all antimicrobial agents. Although most routin antibiotics had no effect on Acinetobacter SPP resistance (100%), but Ceftazidime was the most effective (Resistance 22.2%)
Discussion
Acinetobacter spp. Were the most Frequently isolated microorganism(22%), followed by Stapylococus aureus(14.6%) .Although resistance rates to Acinetobacter SPP. other Strains was very high, but ceftazidime was the most active agent against Acinetobacter SPP. The best options for empirical antibiotic therapy is as follow: Among the cephalosporins, ceftazidime: Among the aminoglycosides, tobramycin and Among Fluoroquinolones, ofloxacin are thebetter option. in this study the death rate beween two groups is not significant. ETA technique was Known as a method for the routine assessment of resistance.
- © 2013 ERS
