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Prevention of ischemia-reperfusion lung injury by supplementation of the preservation solution with an oxygen carrier in porcine lung transplant model

Matthieu Glorion, Pierre-Emmanuel Noly, Benoit DeCante, Fréderic Favreau, Thierry Hauet, Elie Fadel, Edouard Sage
European Respiratory Journal 2013 42: P2672; DOI:
Matthieu Glorion
1Laboratoire De Chirurgie Expérimentale, Université PARIS XI, Hopital Marie Lannelongue, INSERM U999, Le Plessis Robinson, France
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Pierre-Emmanuel Noly
1Laboratoire De Chirurgie Expérimentale, Université PARIS XI, Hopital Marie Lannelongue, INSERM U999, Le Plessis Robinson, France
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Benoit DeCante
1Laboratoire De Chirurgie Expérimentale, Université PARIS XI, Hopital Marie Lannelongue, INSERM U999, Le Plessis Robinson, France
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Fréderic Favreau
2Faculté De Médecine, Université De Poitiers, INSERM U927, Poitiers, France
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Thierry Hauet
2Faculté De Médecine, Université De Poitiers, INSERM U927, Poitiers, France
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Elie Fadel
1Laboratoire De Chirurgie Expérimentale, Université PARIS XI, Hopital Marie Lannelongue, INSERM U999, Le Plessis Robinson, France
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Edouard Sage
1Laboratoire De Chirurgie Expérimentale, Université PARIS XI, Hopital Marie Lannelongue, INSERM U999, Le Plessis Robinson, France
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Abstract

Introduction: Hemo2life is a new natural oxygen carrier extracted from Arenicola marina with high oxygen affinity acting at low temperature. We assessed the effect of Hemo2life associated with a static preservation solution on primary graft dysfunction after lung transplantation.

Material and Methodes: A left lung transplant was performed in pigs after 24 h of preservation at 4°C with Perfadex (Perfadex group, n=5) or with Perfadex® associated with Hemo2life (2g/l) (Hemo2life group, n=5) and compared to a sham animals (n=5). Expression of HIF1α was quantified on iterative samples from the right lung during preservation. During 5 h of lung reperfusion, hemodynamics, oxygenation and dynamic compliance were monitored. HMG-B1, TNFα, and NO were measured in serum. After 5 hours of reperfusion, TNFα and IL-8 were assayed in bronchoalveolar lavage (BAL).

Results : During cold ischemia, expression of HIF1 α and histology remained unchanged and similar to control. After 5 hours of reperfusion, Hemo2life group led to a significant reduction of graft vascular resistance (p<0.05), graft oxygenation ratio was significantly higher (p<0.05). Expression of HMG B1 in serum tended to be lower (2.1+/- 0.8 vs 4.6+/-1.5) compared with Perfadex group. TNF-alpha and IL-8 in BAL were significantly higher in the 2 experimental groups compared to control (p<0,05).

Conclusion : In this preliminary study, adjunction of a new oxygen carrier Hemo2life® in lung preservation solution improves early graft function after prolonged cold ischemia.

  • Transplantation
  • Experimental approaches
  • Lung function testing
  • © 2013 ERS
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Prevention of ischemia-reperfusion lung injury by supplementation of the preservation solution with an oxygen carrier in porcine lung transplant model
Matthieu Glorion, Pierre-Emmanuel Noly, Benoit DeCante, Fréderic Favreau, Thierry Hauet, Elie Fadel, Edouard Sage
European Respiratory Journal Sep 2013, 42 (Suppl 57) P2672;

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Prevention of ischemia-reperfusion lung injury by supplementation of the preservation solution with an oxygen carrier in porcine lung transplant model
Matthieu Glorion, Pierre-Emmanuel Noly, Benoit DeCante, Fréderic Favreau, Thierry Hauet, Elie Fadel, Edouard Sage
European Respiratory Journal Sep 2013, 42 (Suppl 57) P2672;
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