Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

Inflammatory biomarkers as outcome predictors of acute respiratory failure on top of chronic obstructive pulmonary diseases (COPD)

Hanaa Shafiek, Nashwa Abd-Elwahab, Mohamed El-hoffy, Yehia Khalil, Manal Baddour, Akram Degady
European Respiratory Journal 2013 42: P2442; DOI:
Hanaa Shafiek
1Chest Diseases, Alexandria University, Alexandria, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nashwa Abd-Elwahab
1Chest Diseases, Alexandria University, Alexandria, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mohamed El-hoffy
1Chest Diseases, Alexandria University, Alexandria, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yehia Khalil
1Chest Diseases, Alexandria University, Alexandria, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Manal Baddour
1Chest Diseases, Alexandria University, Alexandria, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akram Degady
1Chest Diseases, Alexandria University, Alexandria, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

The aim of the work is to assess the value of interleukin-6 (IL-6), interleukin-8 (IL-8) and C-reactive protein (CRP) in predicting the outcome of acute respiratory failure (ARF) on top of COPD. Methods: Serum samples were collected from 33 patients with COPD presented with ARF for IL-6, IL-8, and CRP analysis on admission and after 72 hours. Sputum samples were taken for microbiological evaluation. Results: Twenty-five patients (75.8%) survived and 8 patients (24.2%) died during the study. Causative microorganism was detected in 66%. Gram-negative and atypical bacteria were the most common pathogen (31% and 28% resp; single or co-pathogen.) without statistically significant association with the outcome (p= 0.262). The IL-6 on admission was significantly higher (p= 0.03) among the non-survivors (257.1 ± 269.1 pg/ml) vs. the survivors (17.9 ± 25.8 pg/ml). The IL-6 level after 72 hours showed statistical significance (p= 0.03) in predicting the outcome as the highest value was among the non-survivors (24.2%) (IL-6= 98.3±153.6 pg/ml), followed by those discharged on oxygen therapy/continuous positive airway pressure (43%) (IL-6= 39.6±88.1 pg/ml) then those discharged on room air (33%) (IL-6=2.2±8.2 pg/ml). Both the CRP and IL-8 were higher among the non-survivors than survivors without significant difference (p >0.05). The CRP level >2.3 mg/L on admission had the best sensitivity of predicting in-hospital mortality (85.7%) and the IL-6 level > 46.1 pg/ml had the best specificity (83%).Conclusions: High IL-6 is associated with in-hospital mortality. Both CRP and IL-6 levels when are used together, they become good in-hospital mortality predictors.

  • Bacteria
  • Ventilation/NIV
  • © 2013 ERS
Previous
Back to top
Vol 42 Issue Suppl 57 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Inflammatory biomarkers as outcome predictors of acute respiratory failure on top of chronic obstructive pulmonary diseases (COPD)
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Inflammatory biomarkers as outcome predictors of acute respiratory failure on top of chronic obstructive pulmonary diseases (COPD)
Hanaa Shafiek, Nashwa Abd-Elwahab, Mohamed El-hoffy, Yehia Khalil, Manal Baddour, Akram Degady
European Respiratory Journal Sep 2013, 42 (Suppl 57) P2442;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Inflammatory biomarkers as outcome predictors of acute respiratory failure on top of chronic obstructive pulmonary diseases (COPD)
Hanaa Shafiek, Nashwa Abd-Elwahab, Mohamed El-hoffy, Yehia Khalil, Manal Baddour, Akram Degady
European Respiratory Journal Sep 2013, 42 (Suppl 57) P2442;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Acquired coagulation disorders during extracorporeal carbon dioxide removal
  • Aggressive treatment of simple pleural effusion in ventilated patients: Pigtail catheters versus thoracostomy
  • Effect of non-patient-level factors on mortality in intensive care units
Show more 2.1 Acute Critical Care

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2021 by the European Respiratory Society