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Serum miR-122 levels correlated to the coagulation disorders of severe sepsis patients

Huijuan Wanghuijuan, Jie Deng, Pengjun Zhang, Xin Zhang, Weijun Chen, Dan Feng, Yanhong Jia, Lixin Xie
European Respiratory Journal 2013 42: P2438; DOI:
Huijuan Wanghuijuan
1Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Hainan, China
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Jie Deng
1Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Hainan, China
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Pengjun Zhang
3Clinical Biochemistry, Chinese PLA General Hospital, Beijing, China
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Xin Zhang
1Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Hainan, China
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Weijun Chen
4Beijing Institute of Genomics, Chinese Academy of Sciences, Airport Industry B6, Beijing, China
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Dan Feng
5Medical Statistics, Chinese PLA General Hospital, Beijing, China
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Yanhong Jia
2Respiratory Medicine, Chinese PLA General Hospital, Beijing, China
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Lixin Xie
1Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Hainan, China
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Abstract

Purpose: miR-122 is a serum signature for liver injury and a prognostic predictor for sepsis patients. Sepsis patients with coagulation abnormalities may be a major impact on the outcome. The aim of our study was to investigate if there were relations between miR-122 and coagulation disorder during sepsis.

Methods: 123 severe sepsis patients were recruited from Intensive Care Units of Chinese PLA general hospital. 24 healthy subjects were selected as normal controls. After collection of the blood samples of these participants, levels of miR-122 were detected by quantitative reverse transcriptase polymerase chain reaction assays (qRT-PCR) and coagulation indexes were detected by Enzyme-Linked Immunosorbnent Assay (ELISA).

Findings: Serum levels of miR-122 were correlated to the serum levels of Activated Partial Thromboplastin Time (APTT) (R=0.426, p=0.008), Fibrinogen (FIB) (R=0.398, p=0.008), Antithrombin III (AT III) (R=0.913, p<0.001). Then, these patients were divided into coagulation abnormal patients and coagulation normal patients. Levels of miR-122 were significantly higher in coagulation abnormal patients than in coagulation normal patients (p=0.029). The area under curve of miR-122 to diagnose coagulation abnormalities was 0.676 (95%CI, 0.533-0.819), p=0.029. When the relative level of serum miR-122 was 0.453, miR-122 generated a sensitivity of 59.4% and a specificity of 77.3%.

Conclusions: Serum levels of miR-122 were correlated to coagulation disorders of sepsis patients.

  • Sepsis
  • Biomarkers
  • Critically ill patients
  • © 2013 ERS
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Serum miR-122 levels correlated to the coagulation disorders of severe sepsis patients
Huijuan Wanghuijuan, Jie Deng, Pengjun Zhang, Xin Zhang, Weijun Chen, Dan Feng, Yanhong Jia, Lixin Xie
European Respiratory Journal Sep 2013, 42 (Suppl 57) P2438;

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Serum miR-122 levels correlated to the coagulation disorders of severe sepsis patients
Huijuan Wanghuijuan, Jie Deng, Pengjun Zhang, Xin Zhang, Weijun Chen, Dan Feng, Yanhong Jia, Lixin Xie
European Respiratory Journal Sep 2013, 42 (Suppl 57) P2438;
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