Abstract
Background: Inflammation is involved in both lung cancer (LC) and cardio-vascular disease (CVD).
Aims: We hypothesize that CVD is an independent risk factor for LC.
Methods: Data from the Nord-Trøndelag Health Study linked to the Norwegian Cancer and Death Cause Registry, analyses stratified by smoking. 97,087 persons (1,634,967 person years), never smokers n=38,656, former smokers n=20,914, current smokers n=26,894, follow-up 15 years. The proportional hazard model (HR CI 95%) for CVD on LC incidence, adjusted for age, sex, BMI, burden of smoking and chronic cough.
Results: LC = 1,080, cases (1.1%), CVD = 5,981 (6.9%). CVD vs LC in former smokers = HR 1.74 (CI95% 1.11-273), current smokers = HR 1.38 (CI95% 1.04-1.83), never smokers = HR 0.87 (CI95% 03.4-2.23).
Table 1
Conclusion: CVD was an independent risk factor for lung cancer in former and current smokers. CVD may be a novel risk factor for lung cancer screening.
- © 2013 ERS
