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Effects of aclidinium bromide on exercise endurance, dynamic hyperinflation, physical activity and exertional dyspnoea in patients with moderate to severe COPD

Kai M. Beeh, Henrik Watz, Helgo Magnussen, Luis Puente-Maestu, Diana Jarreta, Cynthia Caracta, Esther Garcia Gil
European Respiratory Journal 2013 42: 3035; DOI:
Kai M. Beeh
1Medical Director, Insaf Respiratory Research Institute, Wiesbaden, Germany
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Henrik Watz
2Center for Pneumology and Thoracic Surgery, Pulmonary Research Institute GmbH, Grosshansdorf, Germany
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Helgo Magnussen
2Center for Pneumology and Thoracic Surgery, Pulmonary Research Institute GmbH, Grosshansdorf, Germany
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Luis Puente-Maestu
3Servicio De Neumología, Hospital General Universitario Gregorio Marañón/UCM, Madrid, Spain
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Diana Jarreta
4R&D Centre, Almirall, Barcelona, Spain
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Cynthia Caracta
5Forest Research Institute, Forest Laboratories Inc, Jersey City, NJ, United States
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Esther Garcia Gil
4R&D Centre, Almirall, Barcelona, Spain
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Abstract

INTRODUCTION: Lung hyperinflation is related to exertional dyspnoea, exercise intolerance and reduced physical activity in COPD patients.

AIMS: To investigate the effects of aclidinium on dynamic hyperinflation, exercise endurance time, physical activity and dyspnoea in COPD patients.

METHODS: This double-blind, randomized, crossover study compared aclidinium bromide 400 µg BID (metered dose; equivalent to aclidinium 322 µg delivered dose) with placebo, each for 3 weeks, in 112 patients with moderate to severe stable COPD (FEV1 1.50 L, 56.7% pred). Patients performed constant load exercise at 75% of peak incremental exercise work rate. The primary endpoint was change from baseline in endurance time at Week 3. Other assessments were dyspnoea (Borg scale), dynamic inspiratory capacity (dIC) and parameters of physical activity (SenseWear® accelerometer).

RESULTS: see table

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Change from baseline

CONCLUSIONS: Aclidinium significantly improved dynamic hyperinflation, exercise tolerance, physical activity and dyspnoea compared with placebo in COPD patients.

  • COPD - management
  • Exercise
  • Physical activity
  • © 2013 ERS
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Effects of aclidinium bromide on exercise endurance, dynamic hyperinflation, physical activity and exertional dyspnoea in patients with moderate to severe COPD
Kai M. Beeh, Henrik Watz, Helgo Magnussen, Luis Puente-Maestu, Diana Jarreta, Cynthia Caracta, Esther Garcia Gil
European Respiratory Journal Sep 2013, 42 (Suppl 57) 3035;

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Effects of aclidinium bromide on exercise endurance, dynamic hyperinflation, physical activity and exertional dyspnoea in patients with moderate to severe COPD
Kai M. Beeh, Henrik Watz, Helgo Magnussen, Luis Puente-Maestu, Diana Jarreta, Cynthia Caracta, Esther Garcia Gil
European Respiratory Journal Sep 2013, 42 (Suppl 57) 3035;
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