Tables
- Table 1– Predictors of poor outcome among 364 patients with multidrug-resistant (MDR) tuberculosis (TB)
Predictors Treatment success Poor outcome Univariate analysis Multivariate analysis OR# (95% CI) p-value OR# (95% CI) p-value Patients n 226 138 Age years ≥40 111 (49.1) 76 (55.1) 1.0 <40 115 (59.2) 62 (44.9) 0.79 (0.52–1.20) 0.270 Sex Female 73 (32.3) 32 (23.2) 1.0 Male 153 (67.7) 106 (76.8) 1.58 (0.97–2.56) 0.064 Country of birth Portugal 184 (81.4) 107 (77.5) 1.0 Foreign 42 (18.6) 31 (22.5) 1.27 (0.75–2.14) 0.370 Risk factors¶ None 133 (62.1) 63 (48.8) 1.0 Alcohol abuse only 39 (18.2) 22 (17.1) 1.19 (0.65–2.17) 0.570 Injection drug use only 12 (5.6) 19 (14.7) 3.34 (1.53–7.31) 0.003 Alcohol abuse and injection drug use 1 (0.5) 5 (3.9) 10.56 (1.21–92.25) 0.033 Other 29 (13.6) 20 (15.5) 1.46 (0.77–2.77) 0.253 HIV status+ Negative 174 (79.5) 72 (53.3) 1.0 1.0 Positive 45 (20.5) 63 (46.7) 3.38 (2.11–5.42) <0.001 3.56 (2.20–5.77) <0.001 Treatment history Never treated for TB 141 (62.4) 67 (48.6) 1.0 1.0 Previously treated for TB 85 (37.6) 71 (51.4) 1.76 (1.15–2.70) 0.010 1.72 (1.08–2.74) 0.023 Site of disease Pulmonary 211 (93.4) 123 (89.1) 1.0 Pulmonary and extra-pulmonary 15 (6.6) 15 (10.9) 1.72 (0.81–3.63) 0.158 Chest radiograph§ No cavitation 115 (55.6) 55 (45.8) 1.0 Cavitation 92 (44.4) 65 (54.2) 1.48 (0.94–2.32) 0.090 Resistance to kanamycin No 170 (75.2) 85 (61.6) 1.0 1.0 Yes 56 (24.8) 53 (38.4) 1.89 (1.20–2.99) 0.006 1.68 (1.02–2.75) 0.040 Categories of drug resistance MDR 170 (75.2) 87 (63.0) 1.0 XDR 56 (24.8) 51 (37.0) 1.78 (1.13–2.82) 0.014 Data are presented as n (%) unless otherwise stated. XDR: extensively drug-resistant. #: crude and adjusted odds ratio (OR) for poor outcome; ¶: treatment success n=214 and poor outcome n=129; +: treatment success n=219 and poor outcome n=135; §: treatment success n=207 and poor outcome n=120.
Vol 42 Issue 6
Table of Contents
Predictors of treatment outcome in multidrug-resistant tuberculosis in Portugal
