Total | 12 704 (100) | 1.52 | 1.31–1.73 | 6.95 | 6.51–7.39 | 2.66 | 2.38–2.94 |
Age years | | | | | | | |
15–35 | 1562 (12.3) | 1.54 | 0.93–2.15 | 2.62 | 1.83–3.42 | 0.26 | 0.01–0.51 |
36–50 | 2426 (19.1) | 0.95 | 0.56–1.33 | 3.38 | 2.66–4.10 | 0.21 | 0.03–0.39 |
51–65 | 2760 (21.7) | 1.30 | 0.88–1.73 | 5.62 | 4.76–6.47 | 0.83 | 0.49–1.17 |
66–75 | 2354 (18.5) | 1.49 | 1.00–1.98 | 8.58 | 7.45–9.71 | 1.78 | 1.25–2.32 |
76–84 | 2445 (19.3) | 1.96 | 1.41–2.51 | 10.55 | 9.33–11.77 | 5.07 | 4.20–5.94 |
≥85 | 1157 (9.1) | 2.33 | 1.46–3.20 | 12.53 | 10.62–14.44 | 12.10 | 10.22–13.98 |
Sex | | | | | | | |
Males | 6428 (50.6) | 1.70 | 1.38–2.01 | 7.72 | 7.06–8.37 | 2.54 | 2.15–2.92 |
Females | 6276 (49.4) | 1.34 | 1.05–1.62 | 6.17 | 5.57–6.76 | 2.79 | 2.38–3.20 |
Trimester of diagnosis | | | | | | | |
First | 4229 (33.3) | 0.92 | 0.63–1.21 | 6.08 | 5.36–6.80 | 2.39 | 1.93–2.85 |
Second | 3097 (24.4) | 1.94 | 1.45–2.42 | 6.59 | 5.71–7.46 | 2.55 | 2.00–3.11 |
Third | 2374 (18.7) | 1.81 | 1.27–2.35 | 7.83 | 6.75–8.92 | 3.20 | 2.49–3.91 |
Fourth | 3004 (23.7) | 1.70 | 1.24–2.16 | 7.86 | 6.89–8.82 | 2.73 | 2.15–3.31 |
Number of comorbidities | | | | | | | |
0 | 5079 (40.0) | 1.32 | 1.01–1.63 | 4.33 | 3.77–4.89 | 0.75 | 0.51–0.99 |
1 | 3949 (31.1) | 1.52 | 1.14–1.90 | 6.41 | 5.64–7.17 | 2.20 | 1.75–2.66 |
2 | 2039 (16.1) | 1.72 | 1.15–2.28 | 8.34 | 7.14–9.54 | 4.71 | 3.79–5.63 |
≥3 | 1637 (12.9) | 1.89 | 1.23–2.55 | 14.66 | 12.95–16.37 | 7.15 | 5.90–8.40 |
Concurrent therapies | | | | | | | |
Corticosteroids# | 2375 (18.7) | 1.77 | 1.24–2.30 | 8.08 | 6.99–9.18 | 4.00 | 3.21–4.79 |
PPI# | 3043 (24.0) | 1.97 | 1.48–2.47 | 10.35 | 9.27–11.43 | 5.09 | 4.31–5.87 |
Influenza vaccination¶ | 4181 (32.9) | 1.53 | 1.16–1.90 | 10.55 | 9.62–11.48 | 4.74 | 4.09–5.38 |
Pneumococcal vaccination¶ | 785 (6.2) | 1.15 | 0.40–1.89 | 16.82 | 14.2–19.43 | 7.13 | 5.33–8.93 |