GOLD 2011 assessment variables | | | | | |
mMRC dyspnoea score | 0.6 | 2.3 | 0.8 | 2.6 | <0.001 |
FEV1 % pred | 64.2 | 61.6 | 42.2 | 37.2 | <0.001 |
Exacerbations previous 12 months n | 0.2 | 0.3 | 1.0 | 1.3 | <0.001 |
Demographics | | | | | |
Age years | 63.2 | 64.1 | 62.9 | 63.6 | ns |
Females % | 39 | 36 | 31 | 34 | ns |
BMI kg·m−2 | 26.7 | 28.5 | 25.2 | 26.5 | <0.001 |
Smoking pack-years | 48.0 | 47.5 | 45.2 | 51.1 | <0.001 |
Current smokers % | 38 | 34 | 43 | 32 | 0.001 |
Symptoms and comorbidities | | | | | |
Chronic bronchitis % | 26 | 35 | 38 | 38 | <0.001 |
SGRQ-C total score | 31.9 | 55.3 | 44.6 | 62.2 | <0.001 |
Comorbidities n | 2.0 | 2.8 | 1.7 | 2.3 | <0.001 |
Physiology and imaging | | | | | |
FEV1 reversibility % | 11.4 | 11.8 | 10.3 | 10.2 | ns |
SaO2 % | 95.7 | 95.1 | 94.4 | 93.7 | <0.001 |
6MWD m | 440 | 360 | 408 | 307 | <0.001 |
Emphysema CT LLA# % | 11.8 | 12.5 | 18.9 | 22.5 | <0.001 |
Outcomes during follow-up¶ | | | | | |
ECOPDs per year n | 0.6 | 0.9 | 1.3 | 1.7 | <0.001 |
≥1 hospitalisation % | 11 | 25 | 30 | 46 | <0.001 |
Mortality rate % | 4 | 10 | 8 | 14 | <0.001 |
Rate of FEV1 decline mL·year−1 | −33.4 | −38.0 | −30.2 | −31.9 | ns |