Comparative RCTs (pooled) | |
Treatment failure or disease relapse | 15 | 2750 | 4.2 (2.6–5.8) | 2880 | 3.1 (1.9–4.2) | 1.28 (0.99–1.7) | 0 | 0.46 |
Acquired drug resistance | 4 | 1113 | 0.26 (0–0.7) | 1405 | 0.08 (0–0.35) | 1.6 (0.5–5.4) | 0 | 0.04 |
Tuberculosis culture conversion after 2 months of treatment | 12 | 2354 | 94 (91–96) | 2443 | 91 (89–92) | 1.03 (1.01–1.04) | 13 | 0.32 |
Adverse drug reaction | 10 | 2416 | 16 (9–23) | 2195 | 20 (11–28) | 0.88 (0.75–1.03) | 23.7 | 0.23 |
Patients' adherence to treatment# | | |
RCTAI [22]¶ | 1 | 95 | 77 (67–85) | 101 | 73 (64–82) | 1.05 (0.89–1.23) | 66.5 | 0.02 |
Cowie and Brink [23]+ | 1 | 69 | 58 (46–70) | 81 | 84 (74–91) | 0.69 (0.55–0.86) |
Macnab et al. [27]§ | 1 | 121 | 65 (55–73) | 79 | 57 (45–68) | 1.13 (0.90–1.43) |
Teo [33] | 1 | 154 | 95 (90–98) | 153 | 97 (93–99) | 0.97 (0.93–1.02) |
Su and Perng [35]ƒ | 1 | 57 | 70 (57–82) | 48 | 67 (52–80) | 1.05 (0.81–1.37) |
Treatment satisfaction# | | |
Teo [33]## | 1 | 154 | 92 (86–95) | 153 | 90 (84–94) | 1.02 (0.95–1.09) | 97.8 | 0.00 |
Bartacek et al. [17]¶¶ | 1 | 411 | 81 (77–85) | 422 | 57 (52–61) | 1.43 (1.30–1.58) |