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Linezolid to treat extensively drug-resistant TB: retrospective data are confirmed by experimental evidence

Giovanni Sotgiu, Rosella Centis, Lia D'Ambrosio, Antonio Spanevello, Giovanni Battista Migliori on behalf of the International Group for the study of Linezolid
European Respiratory Journal 2013 42: 288-290; DOI: 10.1183/09031936.00191712
Giovanni Sotgiu
1Epidemiology and Medical Statistics Unit, Dept of Biomedical Sciences, University of Sassari, Sassari
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Rosella Centis
2World Health Organization Collaborating Centre for Tuberculosis and Lung Diseases, Fondazione S. Maugeri, Care and Research Institute, Tradate
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Lia D'Ambrosio
2World Health Organization Collaborating Centre for Tuberculosis and Lung Diseases, Fondazione S. Maugeri, Care and Research Institute, Tradate
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Antonio Spanevello
3Università degli Studi dell'Insubria, Varese, and Fondazione S. Maugeri, Care and Research Institute, Tradate, Italy
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Giovanni Battista Migliori
2World Health Organization Collaborating Centre for Tuberculosis and Lung Diseases, Fondazione S. Maugeri, Care and Research Institute, Tradate
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  • For correspondence: giovannibattista.migliori@fsm.it
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  • Table 1– Retrospective evaluation of the safety and tolerability of linezolid in 39 extensively drug-resistant tuberculosis cases
    Adverse eventSubgroup analysis
    LNZ ≤600 mgLNZ >600 mgp-value
    Total adverse events presumably due to linezolid22/34 (64.7)14/20 (70.0)8/14 (57.1)0.49
    Major adverse events21/28 (75.0)16/20 (80.0)5/8 (62.5)0.37
    Anaemia9/29 (31.0)5/21 (23.8)4/8 (50.0)0.21
    Leukopenia4/29 (13.8)1/21 (4.8)3/8 (37.5)0.05
    Thrombocytopenia5/29 (17.2)2/21 (9.5)3/8 (37.5)0.11
    Peripheral neuropathy16/29 (55.2)11/21 (52.4)5/8 (62.5)0.70
    Optic neuritis5/25 (20.0)2/17 (11.8)3/8 (37.5)0.28
    Gastro-intestinal disorders5/28 (17.9)2/21 (9.5)3/7 (42.9)0.08
    Exposure to linezolid days315 (178–540)270 (93–720)330 (270–490)0.64
    • Data are presented as n/n (%) or median (interquartile range), unless otherwise stated. LNZ: linezolid daily dose.

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Linezolid to treat extensively drug-resistant TB: retrospective data are confirmed by experimental evidence
Giovanni Sotgiu, Rosella Centis, Lia D'Ambrosio, Antonio Spanevello, Giovanni Battista Migliori
European Respiratory Journal Jul 2013, 42 (1) 288-290; DOI: 10.1183/09031936.00191712

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Linezolid to treat extensively drug-resistant TB: retrospective data are confirmed by experimental evidence
Giovanni Sotgiu, Rosella Centis, Lia D'Ambrosio, Antonio Spanevello, Giovanni Battista Migliori
European Respiratory Journal Jul 2013, 42 (1) 288-290; DOI: 10.1183/09031936.00191712
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