Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
  • Alerts
  • Podcasts
  • Subscriptions

Identification of asthma clusters in two independent Korean adult asthma cohorts

Tae-Bum Kim, An-Soo Jang, Hyouk-Soo Kwon, Jong-Sook Park, Yoon-Seok Chang, Sang-Heon Cho, Byoung Whui Choi, Jung-Won Park, Dong-Ho Nam, Ho-Joo Yoon, Young-Joo Cho, Hee-Bom Moon, You Sook Cho, Choon-Sik Park for the COREA Study Group
European Respiratory Journal 2013 41: 1308-1314; DOI: 10.1183/09031936.00100811
Tae-Bum Kim
Division of Allergy and Clinical Immunology, Dept of Internal Medicine, Asthma Centre, University of Ulsan College of Medicine, SeoulThese authors contributed equally
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
An-Soo Jang
Dept of Internal Medicine, Genome Research Centre for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, BucheonThese authors contributed equally
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hyouk-Soo Kwon
Division of Allergy and Clinical Immunology, Dept of Internal Medicine, Asthma Centre, University of Ulsan College of Medicine, Seoul
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jong-Sook Park
Dept of Internal Medicine, Genome Research Centre for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, Bucheon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yoon-Seok Chang
Dept of Internal Medicine, Seoul National University College of Medicine, Seoul
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sang-Heon Cho
Dept of Internal Medicine, Seoul National University College of Medicine, Seoul
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Byoung Whui Choi
Dept of Internal Medicine, College of Medicine, Chung-Ang University, Seoul
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jung-Won Park
Dept of Internal Medicine, College of Medicine, Yonsei University, Seoul
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dong-Ho Nam
Dept of Internal Medicine, College of Medicine, Ajou University, Suwon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ho-Joo Yoon
Dept of Internal Medicine, College of Medicine, Hanyang University, Seoul
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Young-Joo Cho
Dept of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hee-Bom Moon
Division of Allergy and Clinical Immunology, Dept of Internal Medicine, Asthma Centre, University of Ulsan College of Medicine, Seoul
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
You Sook Cho
Division of Allergy and Clinical Immunology, Dept of Internal Medicine, Asthma Centre, University of Ulsan College of Medicine, Seoul
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: yscho@amc.seoul.kr
Choon-Sik Park
Dept of Internal Medicine, Genome Research Centre for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, BucheonThese authors contributed equally
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Asthma is a heterogeneous airway disease with various clinical phenotypes. It is crucial to clearly identify clinical phenotypes to achieve better asthma management.

We used cluster analysis to classify the clinical groups of 724 asthmatic patients from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA), and in 1843 subjects from another independent Korean asthma cohort of Soonchunhyang University Asthma Genome Research Centre (SCH) (Bucheon, Republic of Korea). Hierarchical cluster analysis was performed by Ward's method, followed by κ-means cluster analysis.

Cluster analysis of the COREA cohort indicated four asthma subtypes: 1) smoking asthma; 2) severe obstructive asthma; 3) early-onset atopic asthma; and 4) late-onset mild asthma. An independent cluster analysis of the SCH cohort also indicated four clusters that were similar to the COREA clusters.

Our results indicate that adult Korean asthma patients can be classified into four distinct clusters.

  • Asthma
  • classification
  • cluster analysis
  • phenotype

Footnotes

  • This article has supplementary material available from www.erj.ersjournals.com

  • For editorial comments see page 1247.

  • Support Statement

    This study was supported by grants from the Korea Health 21 R&D Project (grant numbers A090548 and A102065) (Ministry of Health, Welfare and Family Affairs, Seoul, Republic of Korea) to C-S. Park, H-B. Moon and Y.S. Cho.

  • Statement of Interest

    None declared.

  • Received June 13, 2011.
  • Accepted September 29, 2012.
  • ©ERS 2013
View Full Text
PreviousNext
Back to top
View this article with LENS
Vol 41 Issue 6 Table of Contents
European Respiratory Journal: 41 (6)
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Identification of asthma clusters in two independent Korean adult asthma cohorts
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
Print
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Identification of asthma clusters in two independent Korean adult asthma cohorts
Tae-Bum Kim, An-Soo Jang, Hyouk-Soo Kwon, Jong-Sook Park, Yoon-Seok Chang, Sang-Heon Cho, Byoung Whui Choi, Jung-Won Park, Dong-Ho Nam, Ho-Joo Yoon, Young-Joo Cho, Hee-Bom Moon, You Sook Cho, Choon-Sik Park
European Respiratory Journal Jun 2013, 41 (6) 1308-1314; DOI: 10.1183/09031936.00100811

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Identification of asthma clusters in two independent Korean adult asthma cohorts
Tae-Bum Kim, An-Soo Jang, Hyouk-Soo Kwon, Jong-Sook Park, Yoon-Seok Chang, Sang-Heon Cho, Byoung Whui Choi, Jung-Won Park, Dong-Ho Nam, Ho-Joo Yoon, Young-Joo Cho, Hee-Bom Moon, You Sook Cho, Choon-Sik Park
European Respiratory Journal Jun 2013, 41 (6) 1308-1314; DOI: 10.1183/09031936.00100811
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
    • METHODS
    • RESULTS
    • DISCUSSION
    • Acknowledgments
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Subjects

  • Asthma and allergy
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

Original Article

  • Targeting Treatable Traits in Severe Asthma: A Randomised Controlled Trial
  • Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases
  • Acute air pollution exposure alters neutrophils in never-smokers and at-risk humans
Show more Original Article

Asthma

  • Does maintenance azithromycin reduce asthma exacerbations?
  • Increased mortality in patients with corticosteroid-dependent asthma
  • Predictors of severe asthma attack re-attendance in children
Show more Asthma

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Collections
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2019 by the European Respiratory Society