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Reduced expression of interferon stimulated genes in refractory asthma

Jane da Silva, Monique Henket, Michael Edwards, Sebastian Johnston, Renaud Louis
European Respiratory Journal 2012 40: P803; DOI:
Jane da Silva
1Department of Medicine and Post-Graduate Program in Health Science, University of South of Santa Catarina - UNISUL, Tubarao, SC, Brazil
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Monique Henket
2Department of Pneumology, GIGA I 3 Research group, CHU, University of Liege, Liege, Belgium
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Michael Edwards
3Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom
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Sebastian Johnston
3Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom
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Renaud Louis
2Department of Pneumology, GIGA I 3 Research group, CHU, University of Liege, Liege, Belgium
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Abstract

Introduction: Patients with refractory asthma are more susceptible to allergen- and infection-induced exacerbations. This susceptibility is poorly understood, but it may be related to an inefficient activation of innate host defence pathways. Interferon-stimulated genes (ISGs), such as myxovirus resistance (MX1), 2'5'-oligoadenylate synthetase (OAS) and viperin are associated to biological activities, including antiviral, antiproliferative, and proapoptotic effects.

Objective: The aim of the study was investigate the expression of antiviral genes in patients with refractory compared with moderate and mild asthma.

Methods: The mRNA expression of the ISGs (MX1, OAS and viperin), interferon (IFN) type I (β) and type III (IL-28 and IL-29) were measured by RTq-PCR in cells of induced sputum from 19 healthy subjects, 19 mild, 22 moderate and 22 refractory asthmatics.

Results: The mRNA expression of Mx1 and viperin was significantly reduced in refractory asthmatics (p=0,04 and p= 0,03, respectively), while the mRNA expression of OAS, IFNβ, IL-28 and IL-29 was not different between groups.

Conclusion: The results point to a deficient innate immune response in refractory asthmatics demonstrated by a decreased expression of some interferon stimulated genes.

  • Asthma - mechanism
  • Molecular pathology
  • Immunology
  • © 2012 ERS
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Reduced expression of interferon stimulated genes in refractory asthma
Jane da Silva, Monique Henket, Michael Edwards, Sebastian Johnston, Renaud Louis
European Respiratory Journal Sep 2012, 40 (Suppl 56) P803;

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Reduced expression of interferon stimulated genes in refractory asthma
Jane da Silva, Monique Henket, Michael Edwards, Sebastian Johnston, Renaud Louis
European Respiratory Journal Sep 2012, 40 (Suppl 56) P803;
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